(2S)-N-{5-[2-(2-methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methylisoquinolin-6-yl)ethynyl]pyridin-2-yl}-2-(methylamino)propanamide | 1875100-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (2S)-N-{5-[2-(2-methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methylisoquinolin-6-yl)ethynyl]pyridin-2-yl}-2-(methylamino)propanamide
• 英文别名: XE77D7Fkw4；(2S)-N-[5-[2-(2-methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methylisoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide
• CAS: 1875100-07-4
• 化学式: C₃₅H₃₁N₇O₂
• 分子量: 581.677
• InChiKey: XPQTUUJPXMXNET-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  44
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] 6-ALKYNYL-PYRIDINE DERIVATIVES AS SMAC MIMETICS<br/>[FR] DÉRIVÉS 6-ALCYNYLPYRIDINES UTILISABLES COMME MIMÉTIQUES DE SMAC
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2016023858A1

  公开（公告）日：2016-02-18

  This invention relates to 6-alkynyl-pyridine of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R4 have the meanings given in the claims and in the specification.

  本发明涉及一般式（I）的6-炔基吡啶，其用作SMAC模拟剂，含有它们的药物组合物，以及它们作为治疗和/或预防由过度或异常细胞增殖和相关疾病条件（如癌症）特征的药物。基团R1到R4的含义如索赔和规范中所述。
• 6-ALKYNYL-PYRIDINE DERIVATIVES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160039814A1

  公开（公告）日：2016-02-11

  6-Alkynyl-pyridine of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. An exemplary compound is

  6-炔基吡啶通式(I)，它们可用作SMAC类似物，含有它们的制药组合物，并用作治疗和/或预防由过度或异常细胞增殖引起的疾病及相关病症，如癌症的药物。其中一个典型化合物是：
• 6-alkyny-pyridine derivatives
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10413536B2

  公开（公告）日：2019-09-17

  6-Alkynyl-pyridine of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. An exemplary compound is

  通式 (I) 的 6-炔基吡啶 它们作为 SMAC 拟效物的用途、含有它们的药物组合物，以及它们作为治疗和/或预防以细胞过度或异常增殖为特征的疾病和癌症等相关疾病的药物的用途。 一个示例化合物是
• 6-ALKYNYL-PYRIDINE DERIVATIVES AS SMAC MIMETICS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP3180339B1

  公开（公告）日：2018-12-05
• 6-Alkynyl-pyridine Derivatives
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180015082A1

  公开（公告）日：2018-01-18

  6-Alkynyl-pyridine of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. An exemplary compound is