2-n-butyl-5,10-dimethoxy-1,2,3,4-tetrahydrobenz[g]isoquinoline | 1037294-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-n-butyl-5,10-dimethoxy-1,2,3,4-tetrahydrobenz[g]isoquinoline
• CAS: 1037294-69-1
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.413
• InChiKey: YBOANPNPTMHCNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.02
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  21.7
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-n-butyl-5,10-dimethoxy-1,2,3,4-tetrahydrobenz[g]isoquinoline 在 silver(II) oxide 、 硝酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 生成 2-n-butyl-1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione
  参考文献：
  名称：

  Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.03.014
• 作为产物：
  描述：

  2-n-butyl-5,10-dimethoxy-1,4-dihydrobenzo[g]isoquinolin-3(2H)-one 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 16.0h， 以32%的产率得到2-n-butyl-5,10-dimethoxy-1,2,3,4-tetrahydrobenz[g]isoquinoline
  参考文献：
  名称：

  Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.03.014