Microbial-catalysed resolution of sterically demanding cyanohydrins
摘要:
Mycelia containing carboxyl-esterases, a novel source of enzymes, have been investigated in the hydrolytic kinetic resolution of one type of tert-alcohols, alpha,alpha-disubstituted cyanohydrins. This class of enzymes Was found to be both active and selective towards these tert-alcohols, giving E-values as high as 42. (C) 2009 Elsevier B.V. All rights reserved.