N'-cyclohexyl-N,2-diphenyl-2-(phenylamino)acetimidamide | 18742-16-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-cyclohexyl-N,2-diphenyl-2-(phenylamino)acetimidamide
• 英文别名: N,N'-Diphenyl-1-phenyl-2-cyclohexylimino-ethylendiamin
• CAS: 18742-16-0
• 化学式: C₂₆H₂₉N₃
• 分子量: 383.536
• InChiKey: CCQLBLKSDVODDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.68
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  36.42
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  异氰环已烷 、 N-苄叉苯胺 在 三氟化硼乙醚 作用下， 以 乙醚 为溶剂， 生成 N'-cyclohexyl-N,2-diphenyl-2-(phenylamino)acetimidamide
  参考文献：
  名称：

  Acid-catalyzed reaction of isocyanide with a Schiff base. New and facile syntheses of imidazolidines

  摘要：

  DOI：

  10.1021/jo01256a090

文献信息

• Odorless Isocyanide Chemistry: An Integrated Microfluidic System for a Multistep Reaction Sequence
  作者：Siddharth Sharma、Ram Awatar Maurya、Kyoung-Ik Min、Guan-Young Jeong、Dong-Pyo Kim

  DOI：10.1002/anie.201303213

  日期：2013.7.15

  continuous‐flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul‐smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N‐substituted formamides, and several representative isocyanide‐based organic reactions were successfully performed. DIPEA=N,N‐diisopropylethylamine.

  不能闻到：集成的连续流微流控装置可在几乎不暴露于环境的情况下原位产生，提取，分离异味异氰酸酯并进行反应。异氰酸酯是由相应的N-取代的甲酰胺脱水生成的，成功地进行了几种基于异氰酸酯的代表性有机反应。DIPEA = N，N-二异丙基乙胺。
• Silica gel promoted environment-friendly synthesis of α-amino amidines and regioselective transformation of α-amino amidines into amidino substituted indazoles
  作者：A. Sagar、Venkata Nagarjuna Babu、Duddu. S. Sharada

  DOI：10.1039/c5ra02491a

  日期：——

  Ugi-type strategy (U-3CR) for the synthesis of a wide variety of α-amino amidines has been developed by using silica gel as promoter, and a novel access to amidino substituted indazoles in a regioselective manner is presented via iron(III) catalyzed post Ugi cyclization strategy. This method allows an easy construction of amidino substituted indazoles in good yields with broad substrate scope starting from

  通过使用硅胶作为促进剂，开发了用于合成多种α-氨基am的环保型三组分Ugi型策略（U-3CR），并且以区域选择性方式新颖地获得了mid基取代的吲唑。呈现经由铁（III）催化的张贴的Ugi环化策略。该方法允许容易地以良好的产率构建construction基取代的吲唑，并且具有从容易获得的起始原料开始的广泛的底物范围。
• Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
  作者：Praveen Reddy Adiyala、D Chandrasekhar、Jeevak Sopanrao Kapure、Chada Narsimha Reddy、Ram Awatar Maurya

  DOI：10.3762/bjoc.10.214

  日期：——

  A facile and efficient synthetic protocol for the synthesis of alpha-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields.

  使用分子碘催化的异氰化物、胺和醛的三组分偶联反应开发了一种用于合成 α-氨基脒的简便有效的合成方案。所提出的策略具有反应条件温和、环境影响低、方法清洁简单、原子经济性高、底物范围广和产率高等优点。