4-methoxy 4'-bromomethyl stilbene | 14366-75-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-methoxy 4'-bromomethyl stilbene
• 英文别名: 4-(4-Methoxystyryl)benzylbromid；4-Brommethyl-4'-methoxy-stilben；4-(4-Methoxystyryl)benzyl bromide；1-(bromomethyl)-4-[2-(4-methoxyphenyl)ethenyl]benzene
• CAS: 14366-75-7
• 化学式: C₁₆H₁₅BrO
• 分子量: 303.198
• InChiKey: JKGJVMSPQYACMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-methoxy 4'-bromomethyl stilbene 在 氢氧化钾 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 methyl-[4'-(4-styryl-styryl)-stilben-4-yl]-ether
  参考文献：
  名称：

  Erckel, R.; Fruehbeis, H., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982, vol. 37, # 11, p. 1472 - 1480

  摘要：

  DOI：
• 作为产物：
  描述：

  (E)-4'-methoxy-4-methylstilbene 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 为溶剂， 反应 6.0h， 以57%的产率得到4-methoxy 4'-bromomethyl stilbene
  参考文献：
  名称：

  Synthesis and calcium antagonistic activity of diethyl styrylbenzylphosphonates

  摘要：

  Twenty-three new phosphonic ester derivatives of stilbene exhibiting structural analogies with fostedil are described. Examination of calcium antagonism showed that this activity could not be increased by introducing electron-withdrawing, electron-releasing or lipophilic substituents. Only compounds containing fluorine at the 2 or 4 positions exhibited similar activity to the model.

  DOI：

  10.1016/0223-5234(94)90204-6

文献信息

• Aromatic diketones
  申请人：Sterling Drug Inc.

  公开号：US04153719A1

  公开（公告）日：1979-05-08

  Beta-diketones substituted by an aryl-aliphatic group in which the aliphatic chain is interrupted by a cyclic group, and useful as anti-viral agents, are prepared by interacting the appropriate aryl-aliphatic halide with an alkali metal salt of a beta-diketone.

  一种由芳基-脂肪族基取代的Beta-二酮，其中脂肪链被环状基团打断，并且可用作抗病毒剂，是通过将适当的芳基-脂肪族卤代物与Beta-二酮的碱金属盐相互作用制备的。
• Synthesis and calcium antagonistic activity of diethyl styrylbenzylphosphonates
  作者：S Younes、G Tchani、G Baziard-Mouysset、JL Stigliani、M Payard、R Bonnafous、J Tisne-Versailles

  DOI：10.1016/0223-5234(94)90204-6

  日期：1994.1

  Twenty-three new phosphonic ester derivatives of stilbene exhibiting structural analogies with fostedil are described. Examination of calcium antagonism showed that this activity could not be increased by introducing electron-withdrawing, electron-releasing or lipophilic substituents. Only compounds containing fluorine at the 2 or 4 positions exhibited similar activity to the model.
• Erckel, R.; Fruehbeis, H., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982, vol. 37, # 11, p. 1472 - 1480
  作者：Erckel, R.、Fruehbeis, H.

  DOI：——

  日期：——