3,12-dioxo-chola-4,6-dien-24-oic acid methyl ester | 102399-65-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3,12-dioxo-chola-4,6-dien-24-oic acid methyl ester
• 英文别名: 3,12-Dioxo-chola-4,6-dien-24-saeure-methylester
• CAS: 102399-65-5
• 化学式: C₂₅H₃₄O₄
• 分子量: 398.543
• InChiKey: KNBWWALNGCNDEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.68
• 重原子数：
  29.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  60.44
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  12α-hydroxy-3-oxo-chola-4,6-dien-24-oic acid methyl ester 在 chromium(VI) oxide 作用下， 生成 3,12-dioxo-chola-4,6-dien-24-oic acid methyl ester
  参考文献：
  名称：

  Adenocarcinoma of the nonpigmented ciliary epithelium: report of two cases with immunohistochemical findings

  摘要：

  Background: Acquired neoplasms arising from the nonpigmented ciliary epithelium (NPCE) are much less common than uveal melanocytic proliferations. We report two cases of acquired neoplasms arising from the NPCE with immunohistochemical findings. Methods: Case reports. Results and conclusions: Patient 1 was a 39-year-old man who presented with a pigmented mass behind the iris and secondary exudative retinal detachment. The eye also developed neovascular glaucoma. Patient 2 was a 44-year-old woman with a ciliary body mass but without symptoms. Both of these tumors were classified histologically as low-grade adenocarcinomas of the NPCE from specimens successfully removed by iridocyclectomy. Immunohistochemical findings confirmed the origin of the tumor cells. however. some changes in the immunoreactivity to cytokeratin AE1 and epithelial membrane antigen were found.

  DOI：

  10.1007/s004170100353

文献信息

• Tamaki, Journal of Biochemistry, 1958, vol. 45, p. 693,695
  作者：Tamaki

  DOI：——

  日期：——