3,4-dihydroxy-5-ethyl-2(5H)-furanone | 212612-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 3,4-dihydroxy-5-ethyl-2(5H)-furanone
• 英文别名: 2-ethyl-3,4-dihydroxy-2H-furan-5-one
• CAS: 212612-47-0
• 化学式: C₆H₈O₄
• 分子量: 144.127
• InChiKey: PRHORHGNSYSVES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CINNAMIC ACID ASCORBATES
  申请人：Rudolph Thomas

  公开号：US20120052028A1

  公开（公告）日：2012-03-01

  The invention relates to specific cinnamic acid ascorbates and to the use thereof as UV filters which bond to the skin, and to a process for the preparation thereof, and to preparations comprising these compounds.

  本发明涉及特定的肉桂酸抗坏血酸盐，并将其用作与皮肤结合的紫外线过滤剂，以及其制备过程和包含这些化合物的制剂。
• Method for resolving racemic mixtures of 5-substituted 4-hydroxy-2-furanones
  申请人：——

  公开号：US20030065196A1

  公开（公告）日：2003-04-03

  This invention affords a solution to the technical problem of obtaining one or both enantiomers of 5-substituted 4-hydroxyfuran-2-ones in pure form by resolution with enantiomerically pure bases. Racemic mixtures of 5-substituted 4-hydroxy-2(5H)-furanones, including 5-substituted and 5,5-disubstituted, 4-hydroxy and 3,4-dihydroxy furanones are separated into pure enantiomers by crystallization with an enantiomerically pure base, such as cinchonidine. In specific solvent mixtures, for example, 95% ethanol, the diastereomerically pure salt of one enantiomer crystallizes. The enantiomerically pure furanone can then be obtained simply by filtration and treatment of the salt with an acid, for example, trifluoracetic acid, followed by precipitation with water, filtration and drying. Moreover, the other enantiomer may be equally obtained in pure form by evaporation of the mother liquor, followed by the same treatment of the salt as described before.

  本发明提供了一种解决技术问题的方法，即通过与对映纯基团分离得到5-取代4-羟基呋喃-2-酮的一个或两个对映体。包括5-取代和5,5-二取代，4-羟基和3,4-二羟基呋喃酮的混合物被晶化与对映纯碱，例如金鸡纳碱，分离成纯对映体。在特定的溶剂混合物中，例如95%的乙醇，一个对映异构体纯盐结晶。然后可以通过过滤和用酸处理盐，例如三氟乙酸，随后用水沉淀，过滤和干燥来获得对映纯呋喃酮。此外，通过蒸发母液，然后用与之前相同的方法处理盐，同样可以获得另一个对映体的纯形式。
• Co-crystals of substituted glycine and uses thereof
  申请人：SyneuRx International (Taiwan) Corp.

  公开号：US10328042B2

  公开（公告）日：2019-06-25

  The present disclosure provides co-crystals of a substituted glycine compound and a co-former compound of Formula (I): compositions comprising such, and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, suicidal ideation and/or behavior, obsessive compulsive disorder or Alzheimer's disease). Also provided herein are methods for preparing the co-crystals.

  本公开提供了一种取代的甘氨酸化合物和一种式（I）的共配体化合物的共晶体： 及其在治疗和/或降低神经精神疾病（如精神分裂症、精神病、抑郁症、自杀意念和/或行为、强迫症或阿尔茨海默病）风险中的用途。本文还提供了制备共晶体的方法。
• METHODS FOR RESOLVING RACEMIC MIXTURES OF 5-SUBSTITUTED 4-HYDROXY-2-FURANONES
  申请人：OXIS Isle of Man, Limited

  公开号：EP1246811B1

  公开（公告）日：2003-12-03
• US6613919B2
  申请人：——

  公开号：US6613919B2

  公开（公告）日：2003-09-02