1,1-Dichlor-2-trimethylsiloxy-cyclopropan | 22085-00-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1,1-Dichlor-2-trimethylsiloxy-cyclopropan
• CAS: 22085-00-3
• 化学式: C₆H₁₂Cl₂OSi
• 分子量: 199.152
• InChiKey: LIDGPHADWCASND-UHFFFAOYSA-N

物化性质

• 沸点：
  177.3±40.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.78
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1,1-Dichlor-2-trimethylsiloxy-cyclopropan 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 以100%的产率得到gem-dichlorocyclopropanol
  参考文献：
  名称：

  Inactivation of S-adenosylhomocysteine hydrolase with haloethyl and dihalocyclopropyl esters derived from homoadenosine-6′-carboxylic acid

  摘要：

  In a search for new inhibitors that exploit 5'-6' `hydrolytic activity' of AdoHcy hydrolase, a new series of haloethyl and dihalocyclopropyl esters 2-3 were designed and their interaction with the enzyme studied. Incubation of the enzyme with 2-3 resulted in time- and concentration-dependent inactivation of AdoHcy hydrolase as well as almost total depletion of its NAD+ content. Further results indicated that the `oxidative' but not the `hydrolytic' activity was involved in the inactivation process. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.050
• 作为产物：
  描述：

  乙烯氧基三甲基硅烷 、 三氯乙酸乙酯 在 sodium methylate 作用下， 以 正戊烷 为溶剂， 以30%的产率得到1,1-Dichlor-2-trimethylsiloxy-cyclopropan
  参考文献：
  名称：

  Inactivation of S-adenosylhomocysteine hydrolase with haloethyl and dihalocyclopropyl esters derived from homoadenosine-6′-carboxylic acid

  摘要：

  In a search for new inhibitors that exploit 5'-6' `hydrolytic activity' of AdoHcy hydrolase, a new series of haloethyl and dihalocyclopropyl esters 2-3 were designed and their interaction with the enzyme studied. Incubation of the enzyme with 2-3 resulted in time- and concentration-dependent inactivation of AdoHcy hydrolase as well as almost total depletion of its NAD+ content. Further results indicated that the `oxidative' but not the `hydrolytic' activity was involved in the inactivation process. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.050

文献信息

• Halomethyl Metal Compounds. IX.¹ The Reaction of Phenyl(bromodichloromethyl)mercury with Alcohols²
  作者：Dietmar Seyferth、Virginia A. Mai、Jeffrey Y.-P. Mui、Kirk V. Darragh

  DOI：10.1021/jo01350a046

  日期：1966.12
• Mechanism-based inactivation of α-chymotrypsin
  作者：Tsuyoshi Ohba、Naoki Tsuchiya、Kuniko Nishimura、Eitatsu Ikeda、Jun Wakayama、Hisashi Takei

  DOI：10.1016/0960-894x(96)00065-0

  日期：1996.3

  The peptidyl ester derivatives of 2,2-dichlorocyclopropanol and the amide derivative of 2,2-dichlorocyclopropylamine were prepred as novel mechanism-based inactivators of alpha-chymotrypsin. The esters inactivated alpha-chymotrypsin irreversibly but the amide did not show any irreversible inhibitory activity toward alpha-chymotrypsin.