4-methoxy-2-[6-(pyrrolidin-1-ylmethyl)-1,3-benzothiazol-2-yl]phenol | 664323-90-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-methoxy-2-[6-(pyrrolidin-1-ylmethyl)-1,3-benzothiazol-2-yl]phenol
• CAS: 664323-90-4
• 化学式: C₁₉H₂₀N₂O₂S
• 分子量: 340.446
• InChiKey: IUTFFLOROGKXEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  73.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NOVEL USE OF BENZOTHIAZOLE DERIVATIVES<br/>[FR] NOUVELLE UTILISATION DE DERIVES DE BENZOTHIAZOLE
  申请人：ASTRAZENECA AB

  公开号：WO2004016600A1

  公开（公告）日：2004-02-26

  The use of compounds of formula (I) wherein X, A, B, D, R1 and R2 are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.

  公开了在制造用于治疗或预防抑制激酶Itk活性有益的药物时，使用式(I)中X、A、B、D、R1和R2如规范中定义的化合物及其药学上可接受的盐。还公开了式(I)的某些新化合物，以及它们的制备方法、含有它们的组合物和它们在治疗中的用途。
• Novel use of benzothiazole derivatives
  申请人：Sjo Peter

  公开号：US20060106015A1

  公开（公告）日：2006-05-18

  The use of compounds of formula (I) wherein X, A, B, D, R 1 and R 2 are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.

  本发明揭示了在制造用于治疗或预防抑制激酶Itk活性有益的疾病或病况的药物中使用式(I)的化合物，其中X、A、B、D、R1和R2如规范中所定义，并且其药学上可接受的盐。本发明还揭示了某些新颖的式(I)化合物，以及它们的制备方法、含有它们的组合物和它们在治疗中的使用。
• NOVEL USE OF BENZOTHIAZOLE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1539723A1

  公开（公告）日：2005-06-15