Estradiol and medroxyprogesterone | 215930-42-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Estradiol and medroxyprogesterone
• 英文别名: (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one;(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• CAS: 215930-42-0
• 化学式: C40H56O5
• 分子量: 616.9
• InChiKey: DWYULUXRGTXBDW-PZRUWWKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.69
• 重原子数：
  45
• 可旋转键数：
  1
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Latex based adsorbent chip
  申请人：Ciphergen Biosystems, Inc.

  公开号：US20030032043A1

  公开（公告）日：2003-02-13

  The present invention provides an adsorbent chip, which includes three components, a substrate, an intermediate layer of linker arms and an adsorbent film, which is attached to the linker arms. The adsorbent film is made up of a plurality of adsorbent particles, each of which includes a binding functionality. The invention also provides a method of making the chips of the invention in which the substrate-intermediate film cassette is formed and the adsorbent film is subsequently immobilized thereon. When the adsorbent film is from the same preparation across a particular batch of chips, the chips provide for the acquisition of data that are highly reproducible from one chip to the next throughout the particular batch of chips. Additionally, the invention provides methods for using the chips to perform assays.

  本发明提供了一种吸附芯片，它包括三个组成部分：基底、中间层连接臂和吸附膜，吸附膜附着在连接臂上。吸附膜由多个吸附颗粒组成，每个吸附颗粒都具有结合功能。本发明还提供了一种制造本发明芯片的方法，在这种方法中，形成基底-中间膜盒，然后将吸附膜固定在其上。当吸附剂薄膜来自同一批芯片的相同制备方法时，该芯片可在整批芯片中从一个芯片到下一个芯片高度重复地获取数据。此外，本发明还提供了使用芯片进行检测的方法。
• PRODRUGS UTILIZING A TRANSPORTER DIRECTED UPTAKE MECHANISM
  申请人：Virginia Commonwealth University

  公开号：EP2624869A2

  公开（公告）日：2013-08-14
• METHOD AND APPARATUS FOR PACKAGING AND DISPENSING PHARMACEUTICALS
  申请人：Tramonte Arturo

  公开号：US20110240504A1

  公开（公告）日：2011-10-06

  A method of packaging one or more pharmaceuticals comprising separating a plurality of unit doses into a plurality of unit dose compartments, wherein each unit dose compartment of the plurality of unit dose compartments holds only one unit dose of the plurality of unit doses, each unit dose having the same strength, wherein the plurality of unit doses is precisely a quantity equal to a most commonly prescribed number of unit doses in individual prescriptions for the unit dose, or a multiple thereof is provided. Also provided are kits prepared by the method. Methods for designing such kits and packaging are also provided.
• PRODRUGS UTILIZING A TRANSPORTER-DIRECTED UPTAKE MECHANISM
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US20130267547A1

  公开（公告）日：2013-10-10

  Prodrugs comprising a lipophilic drug linked to a transport moiety that can be taken up by a fatty acid transporter are provided. The transport moiety comprises a lipid chain connected to a hydrophilic group (e.g. a carboxylic acid, a phosphate, or a sphingosine-like moiety). Due to the presence of the transport moiety, the prodrugs are substrates for endogenous fatty acid transporter systems. The transport moiety thus serves as a carrier or targeting moiety to facilitate uptake of the entire prodrug complex by endogenous fatty acid transporter systems, thereby moving the prodrug into cells and tissues where drug distribution and effects are desired. Hydrolysis of the chemical linkage between the lipid-like moiety and the lipophilic drug releases the drug in an active form within the cells or tissues.
• US7541003B2
  申请人：——

  公开号：US7541003B2

  公开（公告）日：2009-06-02