8-(2,6-diethyl-4-fluorophenylamino)-4-methyl-2H-phthalazin-1-one | 1072157-24-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-(2,6-diethyl-4-fluorophenylamino)-4-methyl-2H-phthalazin-1-one
• 英文别名: 8-(2,6-diethyl-4-fluoroanilino)-4-methyl-2H-phthalazin-1-one
• CAS: 1072157-24-4
• 化学式: C₁₉H₂₀FN₃O
• 分子量: 325.386
• InChiKey: DXUMLEFRFFXMFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  53.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] BLOCKERS OF THE NOGO-A S1PR PATHWAY FOR THE TREATMENT OF DISEASES CHARACTERIZED BY NEURONAL DAMAGE AND LACK OF SUBSEQUENT REPAIR<br/>[FR] BLOQUEURS DE LA VOIX NOGO-A S1PR POUR LE TRAITEMENT DE MALADIES CARACTÉRISÉES PAR UNE LÉSION NEURONALE ET UN DÉFAUT DE RÉPARATION ULTÉRIEURE
  申请人：UNIV ZUERICH

  公开号：WO2012164103A2

  公开（公告）日：2012-12-06

  The present invention provides inhibitors capable of binding to a member of the S1PR receptor group comprised of S1PR2 and S1PR5 with a dissociation constant of 5x10-7 mol/l or smaller for treating neuronal damage, specifically an antibody, an antibody fragment, an antibody-like molecule, a nucleic acid aptamer or an oligopeptide with 6 to 30 amino acid residues in length. Similarly, an interfering RNA or an antisense modulator of gene expression of G13 or a member of the S1PR receptor group described above are provided for treating of neuronal damage.