(6-methoxy-1H-inden-2-yl)-methanol | 916524-98-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: (6-methoxy-1H-inden-2-yl)-methanol
• 英文别名: (6-methoxy-1H-inden-2-yl)methanol
• CAS: 916524-98-6
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: MTENJHRNNXFCFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• MONOAMINE RE-UPTAKE INHIBITORS AND METHODS RELATING THERETO
  申请人：Pontillo Joseph

  公开号：US20060276454A1

  公开（公告）日：2006-12-07

  Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The compounds of this invention have the structure: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m, n, W, X, Y, and Z are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts, esters and solvates thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting monoamine re-uptake in a subject in need thereof.

  单胺再摄取抑制剂，更具体地说是血清素和去甲肾上腺素再摄取抑制剂，被披露具有在男性和女性中治疗中枢或外周神经系统疾病的效用。本发明的化合物具有以下结构： 其中R 1 ，R 2 ，R 3 ，R 4 ，R 5 ，R 6 ，m，n，W，X，Y和Z如本文所定义，包括立体异构体，前药和药学上可接受的盐，酯和溶剂。还披露了含有本发明化合物的组合物与药学上可接受的载体，以及与使用该化合物抑制受需要的主体中的单胺再摄取有关的方法。
• US7378552B2
  申请人：——

  公开号：US7378552B2

  公开（公告）日：2008-05-27
• [EN] MONOAMINE RE-UPTAKE INHIBITORS AND METHODS RELATING THERETO<br/>[FR] INHIBITEURS DE LA RECAPTURE DES MONOAMINES ET METHODES CONNEXES
  申请人：NEUROCRINE BIOSCIENCES INC

  公开号：WO2006133339A2

  公开（公告）日：2006-12-14

  [EN] Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The compounds of this invention have the structure (I) wherein R₁, R₂, R₃, R₄, R₅, R₆, m, n, W, X, Y, and Z are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts, esters and solvates thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting monoamine re-uptake in a subject in need thereof.
  [FR] L'invention concerne des inhibiteurs de la recapture des monoamines, et plus spécifiquement des inhibiteurs de la recapture de la sérotonine et de la noradrénaline, qui peuvent servir au traitement des troubles du système nerveux central ou périphérique aussi bien chez l'homme que chez la femme. Les composés décrits présentent la structure (I), dans laquelle R₁, R₂, R₃, R₄, R₅, R₆, m, n, W, X, Y, et Z sont tels que définis dans la description, ainsi que les stéréoisomères, les promédicaments et sels pharmaceutiquement acceptables, esters et solvates de ces composés. L'invention concerne également des compositions contenant un composé selon la présente invention, combiné à un excipient pharmaceutiquement acceptable, ainsi que des méthodes d'utilisation de ces compositions pour inhiber la recapture des monoamines chez un sujet nécessitant un tel traitement.