4-乙氧基-1-甲氧基-2,2,6,6-四甲基哌啶 | 123373-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-乙氧基-1-甲氧基-2,2,6,6-四甲基哌啶
• 英文名称: 4-Ethoxy-1-methoxy-2,2,6,6-tetramethylpiperidine
• CAS: 123373-72-8
• 化学式: C₁₂H₂₅NO₂
• 分子量: 215.336
• InChiKey: AZFSEKQKXWTDOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  octa acid 、 4-乙氧基-1-甲氧基-2,2,6,6-四甲基哌啶 在 Sodium tetraborate decahydrate 作用下， 以 water-d2 为溶剂， 生成
  参考文献：
  名称：

  Chemistry in Confined Spaces: High-Energy Conformer of a Piperidine Derivative is Favored Within a Water-Soluble Capsuleplex

  摘要：

  Propyloxy-substituted piperidine in solution adopts a conformation in which its alkoxy group is equatorially positioned Surprisingly, two conformers of it that do not interconvert in the NMR time scale at room temperature have been found within an octa-acid capsule The serendipitous finding of the axial conformer of propyloxy-substituted piperidine within a supramolecular capsule highlights the value of confined spaces in physical organic chemistry.

  DOI：

  10.1021/ol101841n
• 作为产物：
  描述：

  溴乙烷 、 阻聚剂701 、 甲基锂 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 、 乙醚 为溶剂， 反应 52.5h， 生成 4-乙氧基-1-甲氧基-2,2,6,6-四甲基哌啶
  参考文献：
  名称：

  Chemistry in Confined Spaces: High-Energy Conformer of a Piperidine Derivative is Favored Within a Water-Soluble Capsuleplex

  摘要：

  Propyloxy-substituted piperidine in solution adopts a conformation in which its alkoxy group is equatorially positioned Surprisingly, two conformers of it that do not interconvert in the NMR time scale at room temperature have been found within an octa-acid capsule The serendipitous finding of the axial conformer of propyloxy-substituted piperidine within a supramolecular capsule highlights the value of confined spaces in physical organic chemistry.

  DOI：

  10.1021/ol101841n

文献信息

• [EN] METHOD FOR PREPARING T-BUTYL 2-((4R,6S)-6-FORMYL-2,2-DIMETHYL-1,3-DIOXAN-4-YL)ACETATE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ACÉTATE DE 2-((4R,6S)-6-FORMYL-2,2-DIMÉTHYL-1,3-DIOXAN-4-YLE) ET DE T-BUTYLE
  申请人：WELL E & C CO LTD

  公开号：WO2012153950A2

  公开（公告）日：2012-11-15

  본 발명은 다양한 HMG-CoA 환원 저해제의 제조에 있어서 핵심 중간체인 광학활성을 갖는 t-부틸 2-((4R,6S)-6-포밀-2,2-디메틸-1,3-디옥산-4-일)아세테이트의 제조방법에 관한 것이다. 본 발명의 제조방법에 따르면, 고분자 지지된 TEMPO를 사용하여 t-부틸 2-((4R,6S)-6-포밀-2,2-디메틸-1,3-디옥산-4-일)아세테이트를 고 순도 및 일정한 순도의 고체로 용이하게 대량 생산할 수 있다.