tert-butyl N-[N'-[(4S)-4-amino-5-(1,3-benzoxazol-2-yl)-5-hydroxypentyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate | 1001646-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: tert-butyl N-[N'-[(4S)-4-amino-5-(1,3-benzoxazol-2-yl)-5-hydroxypentyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate
• CAS: 1001646-67-8
• 化学式: C₂₃H₃₅N₅O₆
• 分子量: 477.561
• InChiKey: KJUZOQDXOZGZAQ-MBIQTGHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Compounds and Compositions as Channel Activating Protease Inhibitors
  申请人：Tully C. David

  公开号：US20070275906A1

  公开（公告）日：2007-11-29

  The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

  该发明提供了化合物及其制药组合物，用于调节通道激活蛋白酶，并使用这些化合物来治疗、改善或预防与通道激活蛋白酶相关的疾病的方法，包括但不限于前列腺蛋白酶、PRSS22、TMPRSS11（例如TMPRSS11B、TMPRSS11E）、TMPRSS2、TMPRSS3、TMPRSS4（MTSP-2）、麦曲蛋白酶（MTSP-1）、CAP2、CAP3、胰蛋白酶、卡特普辛A或中性粒细胞弹性蛋白酶。
• COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS
  申请人：Tully David C.

  公开号：US20110257077A1

  公开（公告）日：2011-10-20

  The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
• US7951823B2
  申请人：——

  公开号：US7951823B2

  公开（公告）日：2011-05-31
• US8338469B2
  申请人：——

  公开号：US8338469B2

  公开（公告）日：2012-12-25
• [EN] COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS EN TANT QU'INHIBITEURS DE PROTÉASES ACTIVATRICES DE CANAL
  申请人：IRM LLC

  公开号：WO2007137080A2

  公开（公告）日：2007-11-29

  [EN] The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
  [FR] L'invention concerne des composés et des compositions pharmaceutiques issues de ces composés convenant pour la modulation de protéases activatrices de canal, ainsi que des méthodes d'utilisation de tels composés pour le traitement, l'amélioration ou la prévention d'un état pathologique associé à des protéases activatrices de canal dont la liste non limitative comprend la prostasine, PRSS22, TMPRSS11 (telles que TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsine, cathepsine A, ou élastase neutrophile.