3-(2-chloro-phenyl)-2-hydroxyimino-propionic acid | 139109-52-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(2-chloro-phenyl)-2-hydroxyimino-propionic acid
• 英文别名: 3-(2-Chlor-phenyl)-2-hydroxyimino-propionsaeure；(2Z)-3-(2-chlorophenyl)-2-hydroxyiminopropanoic acid
• CAS: 139109-52-7
• 化学式: C₉H₈ClNO₃
• 分子量: 213.62
• InChiKey: KBVHACSKAHPTIM-FLIBITNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2-chloro-phenyl)-2-hydroxyimino-propionic acid 在 氢氧化钾 作用下， 生成 邻氯苯乙酸
  参考文献：
  名称：

  Iodine deficiency in Calabria: Characterization of endemic goiter and analysis of different indicators of iodine status region-wide

  摘要：

  The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data were collected during the years 1990-1996. In the inland territory, goiter prevalence ranged from 19 to 64%. At sea level, there was a great variability of goiter prevalence, with values varying from 5.3 to 25.7%. The analysis of the neonatal hypothyroidism screening program data (no.=21,078) showed a 14.8% frequency of TSH levels >5 muU/ml whole blood in newborns from the inland territory and a 14.1% frequency at sea level. Urinary iodine excretion resulted (mean+/-SD) 53.8+/-43.4 mug/l (range: <20 to 189 mu g/1) in the inland territory and 89.6+/-59.8 mu g/l (range: 26 to 333 mu g/l) at sea level. Median urinary iodine excretion values in 13 villages or small towns of the inland territory ranged from 31 to 57 mu g/l. In 2 major towns located at sea level, the median iodine excretion values were 72 mu g/l in Crotone main city and 94 mu g/l in Reggio Calabria main city. The data indicated that moderate, with pockets of severe iodine deficiency is present in the inland region while iodine supply varies from sufficient to marginally low in the coastal areas. Mild iodine deficiency was found in a major town located at sea level.

  DOI：

  10.1007/bf03343991
• 作为产物：
  描述：

  3-(2-氯-苯基)-2-硫代-丙酸 在 乙醇 、 羟胺 作用下， 生成 3-(2-chloro-phenyl)-2-hydroxyimino-propionic acid
  参考文献：
  名称：

  Iodine deficiency in Calabria: Characterization of endemic goiter and analysis of different indicators of iodine status region-wide

  摘要：

  The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data were collected during the years 1990-1996. In the inland territory, goiter prevalence ranged from 19 to 64%. At sea level, there was a great variability of goiter prevalence, with values varying from 5.3 to 25.7%. The analysis of the neonatal hypothyroidism screening program data (no.=21,078) showed a 14.8% frequency of TSH levels >5 muU/ml whole blood in newborns from the inland territory and a 14.1% frequency at sea level. Urinary iodine excretion resulted (mean+/-SD) 53.8+/-43.4 mug/l (range: <20 to 189 mu g/1) in the inland territory and 89.6+/-59.8 mu g/l (range: 26 to 333 mu g/l) at sea level. Median urinary iodine excretion values in 13 villages or small towns of the inland territory ranged from 31 to 57 mu g/l. In 2 major towns located at sea level, the median iodine excretion values were 72 mu g/l in Crotone main city and 94 mu g/l in Reggio Calabria main city. The data indicated that moderate, with pockets of severe iodine deficiency is present in the inland region while iodine supply varies from sufficient to marginally low in the coastal areas. Mild iodine deficiency was found in a major town located at sea level.

  DOI：

  10.1007/bf03343991

文献信息

• Degradation of 3-Aryl-2-hydroxyiminopropionic Acids into Arylacetonitriles Using 1,1'-Carbonyldiimidazole or 2,2'-Oxalyldi(o-sulfobenzimide).
  作者：Tokujiro KITAGAWA、Megumi KAWAGUCHI、Sachie INOUE、Shinji KATAYAMA

  DOI：10.1248/cpb.39.3030

  日期：——

  1, 1'-Carbonyldiimidazole (1) is a useful reagent for the preparation of arylacetonitriles (9) from 3-aryl-2-hydroxyiminopropionic acids (8), and 2, 2'-oxalyldi (o-sulfobenzimide) (2) can also be used for this purpose under essentially neutral conditions.

  1, 1'-碳酰基二咪唑（1）是一种有用的试剂，可以将3-芳基-2-羟基亚氨基丙酸（8）制备成芳基乙腈（9）；而2, 2'-草酸二（邻磺苯并咪唑）（2）在基本中性条件下也可以用于此目的。
• Iodine deficiency in Calabria: Characterization of endemic goiter and analysis of different indicators of iodine status region-wide
  作者：G. Costante、L. Grasso、E. Schifino、M. F. Marasco、U. Crocetti、C. Capula、R. Chiarella、O. Ludovico、M. Nocera、G. Parlato、S. Filetti

  DOI：10.1007/bf03343991

  日期：2002.3

  The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data were collected during the years 1990-1996. In the inland territory, goiter prevalence ranged from 19 to 64%. At sea level, there was a great variability of goiter prevalence, with values varying from 5.3 to 25.7%. The analysis of the neonatal hypothyroidism screening program data (no.=21,078) showed a 14.8% frequency of TSH levels >5 muU/ml whole blood in newborns from the inland territory and a 14.1% frequency at sea level. Urinary iodine excretion resulted (mean+/-SD) 53.8+/-43.4 mug/l (range: <20 to 189 mu g/1) in the inland territory and 89.6+/-59.8 mu g/l (range: 26 to 333 mu g/l) at sea level. Median urinary iodine excretion values in 13 villages or small towns of the inland territory ranged from 31 to 57 mu g/l. In 2 major towns located at sea level, the median iodine excretion values were 72 mu g/l in Crotone main city and 94 mu g/l in Reggio Calabria main city. The data indicated that moderate, with pockets of severe iodine deficiency is present in the inland region while iodine supply varies from sufficient to marginally low in the coastal areas. Mild iodine deficiency was found in a major town located at sea level.