5,8,11-Trioxa-2,14-diazapentadecan | 68960-89-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5,8,11-Trioxa-2,14-diazapentadecan
• 英文别名: N-methyl-2-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethoxy]ethanamine
• CAS: 68960-89-4
• 化学式: C₁₀H₂₄N₂O₃
• 分子量: 220.312
• InChiKey: DQWNGAQNIKMWBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  15
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,8,11-Trioxa-2,14-diazapentadecan 以 氯仿 为溶剂， 反应 48.0h， 生成 2,14,16,21-Tetramethyl-5,8,11-trioxa-1^3,4,15^3,4-tetrathia-1^3a,15^3a-di(λ⁴-thia)-1^1,6,2,14,15^1,6,16,21-octaaza-1,15(2,5)-dipentalenacycloheneicosaphan
  参考文献：
  名称：

  Tittelbach, Franz; Lutze, Gerhard; Graubaum, Heinz, Chemische Berichte, 1994, vol. 127, # 11, p. 2209 - 2214

  摘要：

  DOI：
• 作为产物：
  描述：

  3,6,9-三氧杂十一烷-1,11-二胺 在 硫酸 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 5,8,11-Trioxa-2,14-diazapentadecan
  参考文献：
  名称：

  Bogat-skii, A.V.; Luk'yanenko, N.G.; Shapkin, V.A., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 798 - 804

  摘要：

  DOI：

文献信息

• CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING
  申请人：Reiley Pharmaceuticals, Inc.

  公开号：US20150374858A1

  公开（公告）日：2015-12-31

  Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.

  披露了来自非甾体抗炎药（NSAIDs）的衍生物及其使用方法，这对于识别和定位患者疼痛感觉的病理和/或炎症部位；识别原发、继发、良性或恶性肿瘤的部位；以及诊断感染或确认或排除疑似感染非常有用。基于NSAID的偶联物含有成像基团。这些偶联物在环氧化酶表达增加的部位富集，从而揭示了前列腺素产生增加的部位，这与疼痛和炎症有关，并与肿瘤存在和/或位置有关。识别COX表达增加的区域也有助于筛查感染。
• Immunotropic properties of synthetic macroheterocyclic compounds and their acyclic fragments
  作者：I. É. Britva、T. O. Filippova、N. Ya. Golovenko、Yu. A. Popkov、S. M. Parkhomenko

  DOI：10.1007/bf00767393

  日期：1987.4

  The IR spectra were recorded on a Perkin-Elmer 580B spectrophotometer in tablets with KBr. The PMR spectra were obtained on a Tesla 497 spectrometer (Czechoslovakia) with working frequency i00 MHz; internal standard HMDS. The mass spectra were recorded on a VarianMAT CH-II2 instrument (USA). Thin-layer chromatography was conducted on plates of Silufol UV254 (Czechoslovakia); the chromatograms were

  IR 光谱是在 Perkin-Elmer 580B 分光光度计上用 KBr 记录的。PMR 光谱是在 Tesla 497 光谱仪（捷克斯洛伐克）上获得的，工作频率为 i00 MHz；内标HMDS。质谱记录在 VarianMAT CH-II2 仪器（美国）上。在 Silufol UV254（捷克斯洛伐克）板上进行薄层色谱；用茚三酮乙醚溶液展开色谱图，然后加热至 150-200°。液相色谱我们使用 L 100/160 硅胶。
• Synthetic Multimerizing Agents
  申请人：Holt Dennis A.

  公开号：US20120130076A1

  公开（公告）日：2012-05-24

  New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein.

  新化合物被披露用于多聚免疫蛋白和含有免疫蛋白或免疫蛋白相关域的蛋白质。这些化合物的化学式为M-L-Q，其中M是FKBP蛋白的合成配体。
• ——
  作者：Christopher J. Burns、Leslie D. Field、Jacqueline Morgan、Brian J. Petteys、Jognandan Prashar、Damon D. Ridley、K. R. A. Samankumara Sandanayake、Valentina Vignevich

  DOI：10.1071/ch01111

  日期：——

  In order to optimize the performance of the AMBRI(TM) biosensor (Nature 1997, 387, 580), a variety of hydrophilic linkers between the hydrophobic bilayer membrane and the gold surface have been synthesized. The principal components are prepared from phytanyl hemisuccinate, which is linked by repeating ethylene glycol or propylene glycol units to a second succinic acid unit. The syntheses of analogous substances in which the ester links are replaced by amide and by ether links are also described.
• Kronenether mit 1,3,5-Triazinen als Ringbaustein - Synthese und Untersuchung der Alkaliselektivit�t durch Elektrospray-Ionisations-Massenspektrometrie
  作者：G. Lutze、H. Graubaum、M. Bartoszek、S. Gr�ndemann、S. Flatau

  DOI：10.1002/prac.199633801106

  日期：——

  The synthesis and characterization of 5 new crown compounds 3 and some derivatives 4, containing a 1,3,5-triazine ring as subunit, based on the aminolysis of cyanuric chloride with diamines, is described. The alkali selectivity of some crown ligands were investigated by the ESI mass spectrometry.