7-fluoro-1-methyl-3-phenylnaphthalene | 1325230-31-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-fluoro-1-methyl-3-phenylnaphthalene
• CAS: 1325230-31-6
• 化学式: C₁₇H₁₃F
• 分子量: 236.289
• InChiKey: YUQXETZQWOKZTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 三氟甲磺酸酐 作用下， 以 氯仿 为溶剂， 以70 %的产率得到7-fluoro-1-methyl-3-phenylnaphthalene
  参考文献：
  名称：

  ortho-Alkynyl Benzyl Alcohols as C6 Synthons in Regioselective Construction of Polysubstituted Naphthalenes

  摘要：

  DOI：

  10.1021/acs.joc.4c00491

文献信息

• Cyclization Reaction for the Synthesis of Polysubstituted Naphthalenes in the Presence of Au(I) Precatalysts
  作者：Arun R. Jagdale、Jong Hyub Park、So Won Youn

  DOI：10.1021/jo201339z

  日期：2011.9.2

  Au(I)-catalyzed cyclization of alkenyl carbonyl compounds leading to a variety of substituted naphthalenes has been developed. This process exploits a dual function of the Au(I) catalyst: (1) the oxophilic nature of the Au(I) catalyst, counterintuitive to the pi-acidic reactivities generally associated with Au catalysts, and (2) olefin isomerization supported by the outcome of isotope scrambling experiments. It cannot be completely excluded that TfOH is a true operative catalyst in this protocol. In view of the practicality, the unnecessity of isomerically pure starting material in this reaction is particularly attractive and valuable.