6,7-Dihydro-7,7-di-2-propen-1-yl-5H-pyrrolo[3,4-b]pyridin-5-one | 1213767-13-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 6,7-Dihydro-7,7-di-2-propen-1-yl-5H-pyrrolo[3,4-b]pyridin-5-one
• 英文别名: 7,7-bis(prop-2-enyl)-6H-pyrrolo[3,4-b]pyridin-5-one
• CAS: 1213767-13-5
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: BVXNMECMZVATPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氰基烟酸乙酯 、 3-溴丙烯 在 indium 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以73%的产率得到6,7-Dihydro-7,7-di-2-propen-1-yl-5H-pyrrolo[3,4-b]pyridin-5-one
  参考文献：
  名称：

  Facile synthesis of 3,3-diallyl isoindolones via a indium-mediated double allylation of ortho-cyanobenzoates

  摘要：

  Various 3,3-diallyl isoindolones were synthesized via a indium-mediated Barbier type double allylation reaction of ortho-cyanobenzoates in good yields in short time. The reactivity of nitrile group toward allylindium is sufficient to form a cyclic compound when a suitable electrophilic center is present in the same molecule to trap the imine intermediate. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.034

文献信息

• Facile synthesis of 3,3-diallyl isoindolones via a indium-mediated double allylation of ortho-cyanobenzoates
  作者：Sung Hwan Kim、Se Hee Kim、Ko Hoon Kim、Jae Nyoung Kim

  DOI：10.1016/j.tetlet.2009.12.034

  日期：2010.2

  Various 3,3-diallyl isoindolones were synthesized via a indium-mediated Barbier type double allylation reaction of ortho-cyanobenzoates in good yields in short time. The reactivity of nitrile group toward allylindium is sufficient to form a cyclic compound when a suitable electrophilic center is present in the same molecule to trap the imine intermediate. (c) 2009 Elsevier Ltd. All rights reserved.