2-(4-(Methylamino)-1H-pyrazol-1-yl)ethan-1-ol | 2731007-25-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(4-(Methylamino)-1H-pyrazol-1-yl)ethan-1-ol
• 英文别名: 2-[4-(methylamino)pyrazol-1-yl]ethanol
• CAS: 2731007-25-1
• 化学式: C₆H₁₁N₃O
• 分子量: 141.17
• InChiKey: YCXQDZIPLMEYGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Benzene, Pyridine, and Pyridazine Derivatives
  申请人：Huang Kenneth He

  公开号：US20080119457A1

  公开（公告）日：2008-05-22

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q 1 , Q 2 , Q 3 , R 31 , and R 41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  公开了公式I的化合物和药用盐，其中A、Q1、Q2、Q3、R31和R41如本文所定义。公式I的化合物在治疗与细胞增殖相关的疾病和/或病况方面具有用途，如癌症、炎症、关节炎、血管生成等。还公开了包括本发明化合物的药物组合物以及使用这些化合物治疗上述病况的方法。
• Pyrimidine and Pyrazine Derivatives
  申请人：Huang He Kenneth

  公开号：US20080070930A1

  公开（公告）日：2008-03-20

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R 0 , R 3 , R 7 , n, Q 1 , Q 2 , Y, and X 1 -X 3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明揭示了I式化合物及其药学上可接受的盐，其中R0、R3、R7、n、Q1、Q2、Y和X1-X3如本文所定义。I式化合物在治疗与细胞增殖有关的疾病和/或病况（如癌症、炎症、关节炎、血管生成等）方面具有用途。本发明还揭示了包括本发明化合物的药物组合物和使用这些化合物治疗上述病况的方法。
• Dihydropyridazine, Tetrahydropyridine, Chromanone, and Dihydronaphthalenone Derivatives
  申请人：Huang He Kenneth

  公开号：US20080070918A1

  公开（公告）日：2008-03-20

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q 1 , Q 2 , Q 3 , R 3 , and R 4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明涉及公式I的化合物和药学上可接受的盐，其中A、Q1、Q2、Q3、R3和R4的定义如本文所述。公式I的化合物在治疗与细胞增殖有关的疾病和/或情况，如癌症、炎症、关节炎、血管生成等方面具有用途。本发明还涉及包含本发明化合物的制药组合物以及使用这些化合物治疗上述疾病和情况的方法。
• SUBSTITUTED ARYL COMPOUND
  申请人：Simcere Pharmaceutical Co., Ltd.

  公开号：EP4108663A1

  公开（公告）日：2022-12-28

  The present application describes a substituted aryl compound used as an RAD51 inhibitor and a pharmaceutically acceptable salt thereof. The compound has the structure as represented by Formula (I) and has the substituents and structural features as described in the present application. Furthermore, the present application describes a pharmaceutical composition containing the compound as represented by Formula (I) or the pharmaceutically acceptable salt thereof, and the use of the compound as represented by Formula (I) or the pharmaceutically acceptable salt thereof and the pharmaceutical composition containing same in the preparation of a drug for preventing or treating RAD51 mediated diseases.

  本申请描述了一种用作 RAD51 抑制剂的取代芳基化合物及其药学上可接受的盐。该化合物具有式（I）所代表的结构，并具有本申请中所描述的取代基和结构特征。此外，本申请还描述了一种含有式（I）所代表的化合物或其药学上可接受的盐的药物组合物，以及式（I）所代表的化合物或其药学上可接受的盐和含有该化合物的药物组合物在制备预防或治疗RAD51介导的疾病的药物中的用途。
• Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives
  申请人：Huang Kenneth He

  公开号：US20090093452A1

  公开（公告）日：2009-04-09

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R Q , R 7 , n, Q 2 , Q 3 , Y, and X 1 -X 3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.