1-Chloro-6-(trifluoromethyl)isoquinoline | 1196152-92-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-Chloro-6-(trifluoromethyl)isoquinoline
• CAS: 1196152-92-7
• 化学式: C₁₀H₅ClF₃N
• 分子量: 231.6
• InChiKey: UPVQNMWLCOMNPH-UHFFFAOYSA-N

物化性质

• 沸点：
  296.3±35.0 °C(Predicted)
• 密度：
  1.427±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] AMIDE DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS<br/>[FR] DÉRIVÉS D'AMIDE UTILISÉS EN TANT QUE BLOQUEURS DE NAV1,7 ET DE NAV1,8
  申请人：RAQUALIA PHARMA INC

  公开号：WO2018235851A1

  公开（公告）日：2018-12-27

  The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及酰胺衍生物，具有对Nav1.7和Nav1.8通道的阻塞活性，并且在涉及电压门控钠通道的疾病和疾病的治疗或预防中有用。该发明还涉及包含这些化合物的药物组合物，以及在涉及电压门控钠通道的疾病的预防或治疗中使用这些化合物和组合物。
• Amide derivatives as Nav1.7 and Nav1.8 blockers
  申请人：RaQualia Pharma Inc.

  公开号：US11154544B2

  公开（公告）日：2021-10-26

  The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及对电压门控钠通道（如 Nav1.7 和 Nav1.8 通道）具有阻断活性的酰胺衍生物，它们可用于治疗或预防涉及电压门控钠通道的紊乱和疾病。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的此类疾病中的用途。
• EP3487839B1
  申请人：——

  公开号：EP3487839B1

  公开（公告）日：2020-12-23
• AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS
  申请人：RaQualia Pharma Inc.

  公开号：EP3487839A1

  公开（公告）日：2019-05-29