6-(5-amino-6-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazin-2-yl)-N-ethyl-N,4-dimethylpyridine-3-sulfonamide | 1396773-37-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 6-(5-amino-6-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)pyrazin-2-yl)-N-ethyl-N,4-dimethylpyridine-3-sulfonamide
• 英文别名: 6-[5-amino-6-(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)pyrazin-2-yl]-N-ethyl-N,4-dimethylpyridine-3-sulfonamide
• CAS: 1396773-37-7
• 化学式: C₂₂H₂₄N₆O₃S
• 分子量: 452.537
• InChiKey: XAFBMAZXZRMNQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• MST1 KINASE INHIBITORS AND METHODS OF THEIR USE
  申请人：Augeri David John

  公开号：US20120225857A1

  公开（公告）日：2012-09-06

  Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.

  揭示了用于抑制哺乳动物Ste20样激酶1（MST1）的化合物，以及包含它们的组合物和在治疗、管理或预防炎症性或自身免疫疾病或紊乱中使用它们的方法。
• METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYRDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS
  申请人：Leblond Bertrand

  公开号：US20120225881A1

  公开（公告）日：2012-09-06

  The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.

  以下结构式所示的化合物具有镇痛作用，并用于治疗需要此类治疗的哺乳动物的组合物和方法。
• US8440652B2
  申请人：——

  公开号：US8440652B2

  公开（公告）日：2013-05-14
• US9278943B2
  申请人：——

  公开号：US9278943B2

  公开（公告）日：2016-03-08
• [EN] MST1 KINASE INHIBITORS AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE KINASE MST1 LEURS PROCÉDÉS D'UTILISATION
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2012121992A1

  公开（公告）日：2012-09-13

  Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.