2-(6-methylpyridin-2-yl)-6-pyrrolidin-1-yl-3H-quinazolin-4-one | 733806-48-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(6-methylpyridin-2-yl)-6-pyrrolidin-1-yl-3H-quinazolin-4-one
• CAS: 733806-48-9
• 化学式: C₁₈H₁₈N₄O
• 分子量: 306.367
• InChiKey: JKDWPPIQXAAYOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED QUINAZOLINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4<br/>[FR] DÉRIVÉS DE QUINAZOLINONE SUBSTITUÉS ET LEUR UTILISATION EN TANT QUE MODULATEURS ALLOSTÉRIQUES POSITIFS DE MGLUR4
  申请人：DOMAIN THERAPEUTICS

  公开号：WO2020021064A1

  公开（公告）日：2020-01-30

  The present invention relates to novel quinazolinone derivatives of formula (I) as well as pharmaceutical compositions containing these compounds. The compounds of formula (I) as provided herein can act as positive allosteric modulators of metabotropic glutamate receptor subtype 4 (mGluR4), and can thus be used as therapeutic agents, particularly in the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions or conditions which can be affected by alteration of glutamate level or signalling.