2,6-bis(methacrylamido)pyridine | 1085524-29-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,6-bis(methacrylamido)pyridine
• 英文别名: 2-methyl-N-[6-(2-methylprop-2-enoylamino)pyridin-2-yl]prop-2-enamide
• CAS: 1085524-29-3
• 化学式: C₁₃H₁₅N₃O₂
• 分子量: 245.281
• InChiKey: NXTIDWHAWXBDJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,6-二氨基吡啶 、 甲基丙烯酰氯 在 吡啶 作用下， 反应 3.5h， 以78%的产率得到2,6-bis(methacrylamido)pyridine
  参考文献：
  名称：

  Molecularly imprinted polymer of 5-methyluridine for solid-phase extraction of pyrimidine nucleoside cancer markers in urine

  摘要：

  Normal and modified urinary nucleosides represent potential biomarkers for cancer diagnosis. To selectively extract modified nucleosides, we developed a molecularly imprinted polymer (MIP) of 5-methyluridine as selective material for molecularly imprinted solid-phase extraction (MISPE). The MIPs were obtained from vinyl-phenylboronate ester derivative of the template, acrylamide and pentaerythritol triacrylate co-polymer, and were tested in batch and cartridge experiments with aqueous samples. Our results indicated that the imprinted polymer was selective for pyrimidine nucleosides with a K(d) and a B(max) of 46 mu M and 18 mu mol/g, respectively. Finally, a MISPE of the most common pyrimidine nucleoside cancer markers in urine sample was realized. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.08.063

文献信息

• MOLECULARLY IMPRINTED POLYMERS
  申请人：Hearn Milton T. W.

  公开号：US20120052757A1

  公开（公告）日：2012-03-01

  The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.

  本发明提供了设计分子印迹聚合物（MIPs）的方法，这些方法在从各种生物加工原料和废弃物中提取生物活性化合物方面具有应用。本发明进一步针对由本发明方法设计的MIPs。
• Functional monomers for molecular recognition and catalysis
  申请人：Sellergren Borje

  公开号：US20070106041A1

  公开（公告）日：2007-05-10

  The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The obtained polymers may be used for separation of enantiomers, diastereomers of the template molecule, and also for separation of the template molecule or template molecule analogues from structurally related compounds.

  本发明涉及一种新型可聚合单体，以及通过在模板分子存在下聚合至少一种单体和交联单体而获得的分子印迹聚合物。所获得的聚合物可用于分离模板分子的对映体、对映异构体，并且还可用于分离模板分子或类似物与结构相关化合物。
• Molecularly imprinted polymer for selectively trapping odorous molecules
  申请人：L'ORÉAL

  公开号：US10772823B2

  公开（公告）日：2020-09-15

  The invention relates to the use of molecularly imprinted polymer(s) or MIPs, of odorous molecule(s), as deodorant agent in particular for selectively trapping molecules that are the cause of human body odour. More particularly by using MIPs which may be obtained via polymerization, preferably via radical polymerization, of a mixture of: i) optionally one or more polymerization initiator(s); ii) one or more functional monomer(s); iii) one or more crosslinking agent(s); and iv) one or more porogenic solvent(s); it being understood that the polymerization a) or b) is performed in the presence v) of one or more “templates” of target molecule(s) responsible for human body odour. Another subject of the invention concerns a process for preparing MIPs as defined previously, MIPs obtained via this process, and a cosmetic composition comprising at least one MIP as defined previously. Unexpectedly, it appears that the MIPs make it possible to specifically trap precursors of odorous molecules and odorous molecules that may be used in cosmetic formulations, especially those that are the cause of the unpleasant odour of sweat.

  本发明涉及气味分子的分子印迹聚合物或 MIPs 作为除臭剂的用途，特别是用于选择性地捕获导致人体气味的分子。更具体地说，MIPs 可通过以下混合物的聚合（最好是自由基聚合）获得：i) 一种或多种聚合引发剂；ii) 一种或多种功能性单体；iii) 一种或多种交联剂；iv) 一种或多种致孔溶剂。本发明的另一个主题涉及前文定义的 MIP 制备工艺、通过该工艺获得的 MIP 以及包含至少一种前文定义的 MIP 的化妆品组合物。令人意想不到的是，MIPs 似乎可以专门捕获气味分子的前体和可用于化妆品配方的气味分子，特别是那些导致难闻汗味的分子。
• Molecularly imprinted polymers and their use as antidandruff agents
  申请人：L'ORÉAL

  公开号：US10772822B2

  公开（公告）日：2020-09-15

  The invention relates to a molecularly imprinted polymer obtained by polymerization of a mixture comprising a basic ethylene monomer having an amine group, a crosslinking agent comprising at least 2 polymerizable ethylene unsaturations, a porogenic solvent and a C14-C20 fatty acid. A cosmetic composition comprising such a polymer. A cosmetic process to prevent and/or treat dandruff of the scalp using such a polymer.

  本发明涉及一种分子印迹聚合物，它是通过聚合一种混合物而得到的，该混合物包括 具有胺基团的碱性乙烯单体、包含至少 2 个可聚合乙烯不饱和物的交联剂、致孔溶剂和 C14-C20 脂肪酸。一种包含这种聚合物的化妆品组合物。一种使用这种聚合物预防和/或治疗头皮屑的化妆品工艺。
• MOLECULARLY IMPRINTED POLYMERS AND THEIR USE AS ANTIDANDRUFF AGENTS
  申请人：L'Oréal

  公开号：EP2938641B1

  公开（公告）日：2016-08-24