4-isopropoxy-cinnoline | 4320-59-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-isopropoxy-cinnoline
• 英文别名: 4-Isopropoxy-cinnolin；4-Isopropoxycinnolin；4-Propan-2-yloxycinnoline
• CAS: 4320-59-6
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.229
• InChiKey: IDBYLNIQFFGLEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基喹啉 、 sodium isopropylate 在 异丙醇 作用下， 生成 4-isopropoxy-cinnoline
  参考文献：
  名称：

  Adachi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 1426,1427, 1428

  摘要：

  DOI：

文献信息

• Antiviral compounds
  申请人：Cottell Jeromy J.

  公开号：US20090186869A1

  公开（公告）日：2009-07-23

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及抗病毒化合物、含有该化合物的组合物以及包括该化合物的治疗方法，还涉及用于制备该化合物的过程和中间体。
• N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION
  申请人：C4 Therapeutics, Inc.

  公开号：US20200140456A1

  公开（公告）日：2020-05-07

  This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.
• US8513186B2
  申请人：——

  公开号：US8513186B2

  公开（公告）日：2013-08-20
• Adachi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 1426,1427, 1428
  作者：Adachi

  DOI：——

  日期：——