ethyl 8-fluoro-4-methyl-1-oxo-7-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate | 318685-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: ethyl 8-fluoro-4-methyl-1-oxo-7-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate
• 英文别名: Ethyl 8-fluoro-4-methyl-1-oxo-7-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzo[f][1,7]naphthyridine-2-carboxylate
• CAS: 318685-14-2
• 化学式: C₂₇H₂₄F₄N₄O₃
• 分子量: 528.506
• InChiKey: AQWYIORQVZNMQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  ethyl 8-fluoro-4-methyl-1-oxo-7-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 8-fluoro-4-methyl-1-oxo-7-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylic acid
  参考文献：
  名称：

  Benzo[f]naphtyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens

  摘要：

  The synthesis and antibacterial activity of benzo[f][1,7]naphtyridone derivatives are reported. These compounds are potent antibacterial agents with a Gram-positive spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chemical and biological properties make them particularly suitable for topical antibacterial use. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00057-x
• 作为产物：
  描述：

  1-(3-三氟甲基苯基)哌嗪 、 ethyl 7,8-difluoro-4-methyl-1-oxo-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate 以 二甲基亚砜 为溶剂， 生成 ethyl 8-fluoro-4-methyl-1-oxo-7-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate 、 7-Fluoro-4-methyl-1-oxo-8-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-1,4-dihydro-benzo[f][1,7]naphthyridine-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Benzo[f]naphtyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens

  摘要：

  The synthesis and antibacterial activity of benzo[f][1,7]naphtyridone derivatives are reported. These compounds are potent antibacterial agents with a Gram-positive spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chemical and biological properties make them particularly suitable for topical antibacterial use. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00057-x

文献信息

• Benzo[f]naphthyridine derivatives, their preparation and compositions containing them
  申请人：——

  公开号：US20020137741A1

  公开（公告）日：2002-09-26

  Benzo[f]naphthyridine derivatives of formula (I): 1 benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): 2 aminoquinoline derivatives of formula (X): 3 processes for preparing such compounds; and compositions comprising them.

  苯并［ｆ］萘啉衍生物的化学式（I）：1苯并［ｆ］萘啉衍生物和苯并［ｆ］萘啉酯的化学式（IVa）；2氨基喹啉衍生物的化学式（X）；3制备这些化合物的方法；以及包含它们的组合物。
• US6566362B2
  申请人：——

  公开号：US6566362B2

  公开（公告）日：2003-05-20