3-bis(2-perfluorohexylethyl)methoxy-N-((isopropylimino)methylene)propan-1-amine | 956895-88-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-bis(2-perfluorohexylethyl)methoxy-N-((isopropylimino)methylene)propan-1-amine
• CAS: 956895-88-8
• 化学式: C₂₄H₂₂F₂₆N₂O
• 分子量: 848.41
• InChiKey: MXFKDMWRTBOPGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  53
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  34
• 氢给体数：
  0
• 氢受体数：
  29

反应信息

• 作为反应物：
  描述：

  3-bis(2-perfluorohexylethyl)methoxy-N-((isopropylimino)methylene)propan-1-amine 、 1-甲基吲哚-3-甲酸 、 对氟苄胺 以 二氯甲烷 为溶剂， 反应 3.0h， 以17%的产率得到N-(4-fluorobenzyl)-1-methylindole-3-carboxamide
  参考文献：
  名称：

  Amide Bond Formation with a New Fluorous Carbodiimide:  Separation by Reverse Fluorous Solid-Phase Extraction

  摘要：

  A new fluorous carbodiimide is introduced along with a convenient procedure for amide coupling reactions. Reactions of acids and amines under standard conditions for carbodiimide couplings, followed by simple reverse fluorous solid-phase extraction (FSPE) over standard silica gel, provide the target amide products in good yields and purities. The use of HFE-7100 as a fluorous solvent is crucial for the success of the reverse FSPE.

  DOI：

  10.1021/ol701631m
• 作为产物：
  描述：

  3-bis(2-perfluorohexylethyl)methoxypropan-1-amine 在 溴 、 三乙胺 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 3-bis(2-perfluorohexylethyl)methoxy-N-((isopropylimino)methylene)propan-1-amine
  参考文献：
  名称：

  Amide Bond Formation with a New Fluorous Carbodiimide:  Separation by Reverse Fluorous Solid-Phase Extraction

  摘要：

  A new fluorous carbodiimide is introduced along with a convenient procedure for amide coupling reactions. Reactions of acids and amines under standard conditions for carbodiimide couplings, followed by simple reverse fluorous solid-phase extraction (FSPE) over standard silica gel, provide the target amide products in good yields and purities. The use of HFE-7100 as a fluorous solvent is crucial for the success of the reverse FSPE.

  DOI：

  10.1021/ol701631m

文献信息

• Amide Bond Formation with a New Fluorous Carbodiimide:  Separation by Reverse Fluorous Solid-Phase Extraction
  作者：Carlos del Pozo、Adam I. Keller、Tadamichi Nagashima、Dennis P. Curran

  DOI：10.1021/ol701631m

  日期：2007.10.1

  A new fluorous carbodiimide is introduced along with a convenient procedure for amide coupling reactions. Reactions of acids and amines under standard conditions for carbodiimide couplings, followed by simple reverse fluorous solid-phase extraction (FSPE) over standard silica gel, provide the target amide products in good yields and purities. The use of HFE-7100 as a fluorous solvent is crucial for the success of the reverse FSPE.