5-Piperazin-1-yl-[1,2,4]triazolo[4,3-a]pyridine | 1221508-81-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-Piperazin-1-yl-[1,2,4]triazolo[4,3-a]pyridine
• 英文别名: 5-piperazin-1-yl-[1,2,4]triazolo[4,3-a]pyridine
• CAS: 1221508-81-1
• 化学式: C₁₀H₁₃N₅
• 分子量: 203.247
• InChiKey: NEAUCFKIHVUDSH-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  5-Piperazin-1-yl-[1,2,4]triazolo[4,3-a]pyridine 、 在 polymer supported dicyclohexylcarbodiimide 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists

  摘要：

  Starting from non-peptidic sst(1)-selective somatostatin receptor antagonists, first compounds with mixed sst(1)/sst(3) affinity were identified by directed structural modifications. Systematic optimization of these initial leads afforded novel, enantiomerically pure, highly potent and sst(3)-subtype selective somatostatin antagonists based on a (4S,4aS,8aR)-decahydroisoquinoline-4-carboxylic acid core moiety. These compounds can efficiently be synthesized and show promising PK properties in rodents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.063