<¹²⁵I>-Iodohistamine | 72471-56-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: <¹²⁵I>-Iodohistamine
• 英文别名: 2-(2-(125I)iodanyl-1H-imidazol-5-yl)ethanamine
• CAS: 72471-56-8
• 化学式: C₅H₈IN₃
• 分子量: 235.139
• InChiKey: WFYXQHSRCULCLO-WXROZKTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methylpropoxycarbonyl 2-[(Z)-[(8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-ylidene]amino]oxyacetate 、 <¹²⁵I>-Iodohistamine 生成 2-[(Z)-[(8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-ylidene]amino]oxy-N-[2-(2-(125I)iodanyl-1H-imidazol-5-yl)ethyl]acetamide
  参考文献：
  名称：

  JOUQUEY, A.;SALMON, J.;MOUREN, M.;TOUYER, G.

  摘要：

  DOI：

文献信息

• Characteristics of anti-testosterone antisera produced by bovine serum albumin conjugates of 15.ALPHA.- and 15.BETA.-carboxymethyltestosterone: Use of (125I)iodinated tracers.
  作者：Yoshinori MIYAKE、Minoru SHIGETOSHI、Masaharu KOJIMA

  DOI：10.1248/cpb.38.951

  日期：——

  Each testosterone-[125I]iodinated histamine derivative where[125I)iodinated histamines were linked to respective 15α- and 15β-carboxymethyltestosterone (15α-and 15β-CMT), testosterone-3-(O-carboxymethyl)oxime (T-3-CMO) and testosterone-17β-hemisuccinate (T-17-HS) were tested for their usefulness as radiotracers in testosterone immunoassay. In the use of anti-15α- and 15β-CMT antisera produced in rabbits against 15α- and 15β-CMT-bovine serum albumin (BSA) conjugates, the antisera with 15α- and 15β-CMT-[125I]iodinated tracers showed low sensitivity and somewhat low specificity in comparison with those of the antisera with tritiated testosterone (T-3H). On the other hand, the antisear with T-3-CMO-[125I]iodinated tracer showed high sensitivity but low specificity for 5α-dihydrotestosterone(5α-DHT)in comparison with T-3H. The T-17-HS-[125I]iodinated tracer was not bound to the antisera. In the use of anti-15α- and 15β-CMT antisera produced in rabbits by pretreatment with 15α-carboxymethyl-5α-DHT linked to a copolymer of D-glutamic acid and D-lysine followed by immunization with 15α- and 15β-CMT-BSA, the antisera with homologous[125I]iodinated tracer showed high sensitivity and specificity.

  将[125I]碘代组胺与相应的15α-和15β-羧甲基睾酮（15α-和15β-CMT）、睾酮-3-（O-羧甲基）肟（T-3-CMO）和睾酮-17β-半琥珀酸盐（T-17-HS）结合，测试每种睾酮-[125I]碘代组胺衍生物作为睾酮免疫分析中放射性示踪剂的有效性。在用兔产生的抗15α-和15β-CMT抗血清与15α-和15β-CMT-牛血清白蛋白（BSA）结合物结合时，与含氚化睾酮（T-3H）的抗血清相比，含15α-和15β-CMT-[125I]碘代示踪剂的抗血清灵敏度较低，特异性也较低。另一方面，与T-3H相比，含T-3-CMO-[125I]碘代示踪剂的抗血清对5α-二氢睾酮（5α-DHT）的灵敏度高，但特异性低。T-17-HS-[125I]碘代示踪剂不与抗血清结合。在用兔产生的抗
• JOUQUEY, A.;TOUYER, G.;SALMON, J.;MUREN, M.
  作者：JOUQUEY, A.、TOUYER, G.、SALMON, J.、MUREN, M.

  DOI：——

  日期：——