2-(4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)ethyl acetate | 1173173-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)ethyl acetate
• CAS: 1173173-93-7
• 化学式: C₁₅H₂₂N₂O₄S
• 分子量: 326.417
• InChiKey: NDMHAHDCTFNLIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  66.92
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  三乙烯二胺 、 4-溴苯甲砜 、 potassium acetate 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以43%的产率得到2-(4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)ethyl acetate
  参考文献：
  名称：

  Efficient microwave-assisted three-component one-pot preparation of 1-aryl-4-(2-acetoxyethyl)piperazines and 1-aryl-4-(2-acetoxyethyl)piperidines

  摘要：

  A highly efficient one-pot, three-component microwave-assisted procedure has been developed for the preparation of 1-(para-substituted-aryl)-4-(2-acetoxyethyl)piperazines and 1-(para-substituted-aryl)-4(2-acetoxyethyl)piperidines. Microwave-accelerated heating of electron-deficient aryl halides and potassium acetate with either 1,4-diazabicyclo[2.2.2]octane (DABCO) or quinuclidine at 180 degrees C for 120 min provided the title products in good yields and with general substrate scope. Similarly, subjection of potassium pthalimide instead of potassium acetate to the same conditions provided good yields of 1-arylpiperazines and 1-arylpiperidines containing a 2-phthalimidoethyl substituent at the C-4 position. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.027