5-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]imidazo[1,2-a]pyridin-6-yl]pyrazin-2-amine | 1307240-84-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 英文名称: 5-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]imidazo[1,2-a]pyridin-6-yl]pyrazin-2-amine
• CAS: 1307240-84-1
• 化学式: C₁₈H₂₂N₆
• 分子量: 322.413
• InChiKey: WQMDKEHJRWTCJZ-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  72.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• IMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF
  申请人：Rao Ashwin U.

  公开号：US20120225885A1

  公开（公告）日：2012-09-06

  The present invention relates to novel imidazole compounds, pharmaceutical compositions comprising the imidazole compounds and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: