| 1234514-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1234514-91-0
• 化学式: C₁₆H₁₃ClF₂O₄S
• 分子量: 374.793
• InChiKey: UCERRIXABJSFFI-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  溴乙烷 、 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 [4-(4-Chlorophenyl)sulfonyl-4-ethyl-5,8-difluoro-2,3-dihydrochromen-2-yl]methanol
  参考文献：
  名称：

  Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

  摘要：

  A novel series of tricyclic gamma-secretase inhibitors was designed and synthesized via a conformational analysis of literature compounds. The preliminary results have shown that compounds in this new series have much improved in vitro potency and in vivo profiles. More importantly, they have greatly reduced Notch related toxicity that was associated with previous gamma-secretase inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.080
• 作为产物：
  描述：

  C₁₇H₁₇ClF₂O₄S 在 sodium hydride 作用下， 生成
  参考文献：
  名称：

  Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

  摘要：

  A novel series of tricyclic gamma-secretase inhibitors was designed and synthesized via a conformational analysis of literature compounds. The preliminary results have shown that compounds in this new series have much improved in vitro potency and in vivo profiles. More importantly, they have greatly reduced Notch related toxicity that was associated with previous gamma-secretase inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.080