1-tert-butyl-3-[(E)-(2,4-dihydroxyphenyl)methylideneamino]thiourea | 218795-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-tert-butyl-3-[(E)-(2,4-dihydroxyphenyl)methylideneamino]thiourea
• CAS: 218795-74-5
• 化学式: C₁₂H₁₇N₃O₂S
• 分子量: 267.35
• InChiKey: LTFUAYRGVLQXKC-NTUHNPAUSA-N

物化性质

• 沸点：
  425.3±38.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO：可溶10mg/mL，澄清

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  109
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Use of Formin Agonists in Overcoming Brain Tumor Radio- and Chemo-resistance by Targeting Tumor Microtubes
  申请人：The University of Toledo

  公开号：US20200289440A1

  公开（公告）日：2020-09-17

  Compositions and methods for inhibiting brain tumor proliferation, or for inhibiting or halting TM formation, invasion, and/or proliferation, or for rendering brain tumor cells sensitive to chemotherapy or radiation, or for treating a brain tumor, or for inducing cell death, involving mDia agonists such as IMM01 and IMM02, are described.
• TARGETING OF THE CYTOSKELETON AS A THERAPEUTIC APPROACH FOR NEURODEGENERATIVE DISEASE
  申请人：University of Massachusetts

  公开号：US20220280603A1

  公开（公告）日：2022-09-08

  In some aspects, the disclosure relates to compositions and methods useful for the modulating the function of the nuclear pore and/or nucleocytoplasmic transport (NCT). In some embodiments, the disclosure relates to methods of treatment of a neurodegenerative disease (e.g., amyotrophic lateral sclerosis).