2-Aminophenazin-5,10-dioxid | 26390-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-Aminophenazin-5,10-dioxid
• 英文别名: 2-Phenazinamine 5,10-dioxide；5,10-dioxidophenazine-5,10-diium-2-amine
• CAS: 26390-70-5
• 化学式: C₁₂H₉N₃O₂
• 分子量: 227.222
• InChiKey: LEMMUGAREOZFFY-UHFFFAOYSA-N

物化性质

• 熔点：
  219 °C (decomp)
• 沸点：
  535.3±60.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Aminophenazin-5,10-dioxid 在 sulfur 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 以87%的产率得到2-氨基吩嗪
  参考文献：
  名称：

  一种常用，简便且生态友好的方法，用于使用元素硫还原硝基芳烃，选择性还原聚硝基芳烃和对含N氧化物的杂芳烃进行脱氧

  摘要：

  在过渡金属和无添加剂条件下，已经开发了一种简便易行的方案，用于还原硝基芳烃和杂芳烃N-氧化物脱氧。该策略允许通过简单的混合操作选择性还原聚硝基芳烃，并有效地脱除含有杂芳烃的各种N-氧化物，包括苯并呋喃烷和苯并呋喃，具有广泛的底物范围。

  DOI：

  10.1002/ejoc.202000064

文献信息

• Substituted phenazines and methods of treating cancer and bacterial diseases
  申请人：Rongved Pål

  公开号：US11046678B2

  公开（公告）日：2021-06-29

  Compounds of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds.

  式 (Ia) 或 (Ib) 的化合物，或其药学上可接受的盐、 包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。
• N-OXIDE HETEROCYCLES FOR USE IN THE TREATMENT OF CANCER AND BACTERIAL DISEASES
  申请人：Rongved, Pål

  公开号：EP3555052A1

  公开（公告）日：2019-10-23
• COMPOUNDS
  申请人：RONGVED Pål

  公开号：US20200095237A1

  公开（公告）日：2020-03-26

  The invention provides compounds of general formula (I′), and their pharmaceutically acceptable salts: wherein: Z is a group having the formula: -T-S-A-Y in which: T is a group selected from —O—, —NH—, —S—, —(XCR 7 R 8 )— (where R 7 and R 8 is independently —H or C 1-3 alkyl and X is selected from from —O—, —NH—, —S—); S is —(C═O)—, —(SO 2 )—, —(PO 2 )—; A, —O—, —NH—, —S— or —NH(CO)—, —(CR 7 R 8 X)— (where R 7 and R 8 is independently —H or C 1-3 alkyl and X is selected from from —O—, —NH—, —S—), -T-S-A- is a group susceptible to hydrolytic and/or enzymatic cleavage in vivo to leave a group selected from —OH, —NH 2 , —SH, —COOH, —CONH 2 , —O—(CR 7 R 8 )—COOH and —(CR 7 R 8 )—CONH 2 ; Y is one or more targeting groups or a lipophilic or hydrophilic group affecting the solubility in water and the biodistribution in a living organism or a living cell; R 1 -R 6 are independently selected from hydrogen, halogen (e.g. F, Cl, Br, I), lower alkyl (e.g. C 1-6 alkyl), optionally substituted with an acidic group which is —COOH, —SO 3 H, —PO 3 H 2 or —B(OH) 2 . Such compounds find particular use as anti-neoplastic and anti-infective agents.
• SUBSTITUTED PHENAZINES AND METHODS OF TREATING CANCER AND BACTERIAL DISEASES
  申请人：Rongved Pål

  公开号：US20210292313A1

  公开（公告）日：2021-09-23

  A combination product comprising a carbapenem and a compound of formula (I′), or a pharmaceutically acceptable salt thereof: a pharmaceutical composition comprising the combination product; and methods of treating bacterial or fungal infections using the combination product and pharmaceutical composition.
• US5637591A
  申请人：——

  公开号：US5637591A

  公开（公告）日：1997-06-10