3-(2-Hydroxy-3-dodecyloxy-propyl)-chinazol-(4)-on | 5271-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(2-Hydroxy-3-dodecyloxy-propyl)-chinazol-(4)-on
• 英文别名: 3-(2-Hydroxy-3-dodecyloxy-propyl)-chinazolon-(4)；3-(3-dodecyloxy-2-hydroxy-propyl)-3H-quinazolin-4-one；3-(3-Dodecoxy-2-hydroxypropyl)quinazolin-4-one
• CAS: 5271-14-7
• 化学式: C₂₃H₃₆N₂O₃
• 分子量: 388.55
• InChiKey: YMVYKFMHPJHDHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• US5891881A
  申请人：——

  公开号：US5891881A

  公开（公告）日：1999-04-06
• US5972982A
  申请人：——

  公开号：US5972982A

  公开（公告）日：1999-10-26
• [EN] AMINOHETEROCYCLE-SUBSTITUTED GLYCEROLS<br/>[FR] GLYCEROLS A SUBSTITUTION AMINOHETEROCYCLIQUE
  申请人：CLARION PHARMACEUTICALS INC

  公开号：WO2000059906A1

  公开（公告）日：2000-10-12

  Aminoheterocycle-substituted glycerols of Formula (I) are disclosed wherein one of A, B, or C is -X-R, wherein X is -O- or -S-, and R is a substituted or unsubstituted C12-24 alkyl or alkenyl, the substituent being one or more of halo, C1-3 alkoxy or cyano, provided that a double bond of the alkenyl does not originate at the carbon atom bound to X; and another of A, B or C is an aminoheterocycle ring substituent -Het-NH2, wherein Het is a 5 to 11-membered monocyclic, bicyclic or bicyclic fused heterocyclic ring moiety with at least 1 to 4 nitrogen atoms contained within the heterocyclic moiety, one of which nitrogen atoms is bonded to the glycero carbon; and the remaining A, B, or C substituent is -OH. The compounds of Formula (I), isomers, salts, pharmaceutical compositions and appliances incorporating the same, and methods of use thereof are also disclosed.