2-methoxy-N,N'-dimethyl-propanediyldiamine | 854650-95-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-methoxy-N,N'-dimethyl-propanediyldiamine
• 英文别名: 2-Methoxy-N,N'-dimethyl-propandiyldiamin；N.N'-Dimethyl-β-methoxy-trimethylendiamin；1.3-Bis-methylamino-2-methoxy-propan；2-methoxy-N,N'-dimethylpropane-1,3-diamine
• CAS: 854650-95-6
• 化学式: C₆H₁₆N₂O
• mdl: MFCD19219506
• 分子量: 132.206
• InChiKey: CNMMETFHNCNZOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxy-N,N'-dimethyl-propanediyldiamine 在 甲苯 作用下， 生成 N-diethylcarbamoyl-2-methoxy-N,N'-dimethyl-N'-(piperidine-1-carbonyl)-propanediyldiamine
  参考文献：
  名称：

  293.呼吸兴奋剂。第二部分 衍生自2：2'-二氨基二乙醚和1：3-二氨基-2-烷氧基丙烷的完全取代的Bisureas

  摘要：

  DOI：

  10.1039/jr9490001378
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 sodium nitrite 作用下， 生成 2-methoxy-N,N'-dimethyl-propanediyldiamine
  参考文献：
  名称：

  293.呼吸兴奋剂。第二部分 衍生自2：2'-二氨基二乙醚和1：3-二氨基-2-烷氧基丙烷的完全取代的Bisureas

  摘要：

  DOI：

  10.1039/jr9490001378

文献信息

• Sulfonamide compound
  申请人：Matsubara Koki

  公开号：US20090048223A1

  公开（公告）日：2009-02-19

  A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G 1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G 2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; G 3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkoxycarbonyl group, an acyl group, an acyloxy group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; Y represents a single bond, or —C(R 3 )(R 4 )— (R 3 and R 4 represent hydrogen atom, or an alkyl group, or alkylene groups which combine together to form a saturated hydrocarbon ring group); G 4 represents hydroxyl group (Y is a single group), or —N(R 1 )(R 2 ) (R 1 and R 2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, a saturated heterocyclic group, an alkylsulfonyl group, an acyl group, or an amidino group); G 5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits Rho kinase.

  由以下化学式表示的化合物：[A代表含氮饱和环；m表示0到2的整数；n表示1到4的整数；G1代表氢原子、氯原子、羟基、烷氧基或氨基；G2代表卤原子、羟基、氰基、羧基、烷基、烯基、炔基、烷氧基、烷硫基、氨基、烷氧羰基、酰基、乙酰氧基、烷基磺基、烷基磺酰基或芳基；G3代表氢原子、卤原子、羟基、氰基、羧基、烷基、烯基、炔基、烷氧基、烷硫基、氨基、烷氧羰基、酰基、乙酰氧基、烷基磺基、烷基磺酰基或芳基；Y代表单键，或-C(R3)(R4)-（R3和R4代表氢原子、烷基或烷烯基，它们结合在一起形成饱和碳氢环基）；G4代表羟基（Y是单个基），或-N(R1)(R2)（R1和R2代表氢原子、烷基、芳基、烯基、炔基、饱和杂环基、烷基磺酰基、酰基或胺基）；G5是A的环构成碳原子上的取代基，代表氢原子、氟原子或烷基]或其盐、或作为前药的衍生物，其强力抑制Rho激酶。
• Preparation of Polymer Conjugates of Therapeutic, Agricultural, and Food Additive Compounds
  申请人：Konradi Andrei W.

  公开号：US20130018187A1

  公开（公告）日：2013-01-17

  Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.

  揭示了一种使用Mitsunobu条件制备农业、治疗和食品添加剂化合物的高分子共轭物的过程。
• CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS
  申请人：Hangzhou Dac Biotech Co., Ltd.

  公开号：EP3888691A1

  公开（公告）日：2021-10-06

  The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

  本发明涉及具有丙氧基、取代丙烯酰（丙烯酰）或二取代丙酰基团的连接体，以及使用这种连接体将化合物，特别是细胞毒剂与细胞结合分子连接。
• Bisureas
  申请人：ICI LTD

  公开号：US02398283A1

  公开（公告）日：1946-04-09
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.