2-isopropyloxy-7-isopropylnaphthalene | 928153-26-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-isopropyloxy-7-isopropylnaphthalene
• 英文别名: 2-Propan-2-yl-7-propan-2-yloxynaphthalene
• CAS: 928153-26-8
• 化学式: C₁₆H₂₀O
• 分子量: 228.334
• InChiKey: JOXNEZFEUWQKBL-UHFFFAOYSA-N

物化性质

• 沸点：
  331.4±11.0 °C(Predicted)
• 密度：
  0.988±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-isopropyloxy-7-isopropylnaphthalene 在 氢氧化钾 、 三溴化硼 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 生成 1,5-Bis(2-hydroxy-7-propan-2-ylnaphthalen-1-yl)naphthalene-2,6-diol
  参考文献：
  名称：

  Rapid atropisomerization of 1,1′:5′,1″-ternaphthalene-2,2′,6′,2″-tetrol (TERNOL) and its inhibition by tethering at positions 7 and 7″

  摘要：

  Atropisomerization of 1,1':5',1"-temaphthalene-2,2',6',2"-tetrol (TERNOL) is very fast under basic conditions. The stereochemical instability is attributed to the nature of oxide anion of the central 2,6-naphthodiol moiety. Ring-closing metathesis of 7,7"-diallyloxy TERNOL results in intramolecular tethering in a high yield, which intrinsically inhibits the rapid isomerization. Bidentate sites in the tethered TERNOL are proved to have enough structural flexibility as an axial chiral ligand. (c) 2006 Elsevier Ltd, All rights reserved.

  DOI：

  10.1016/j.tet.2006.12.046
• 作为产物：
  描述：

  7-isopropoxynaphthalen-2-ol 在 1,2-双(二苯基膦)乙烷氯化镍 作用下， 以 吡啶 、 乙醚 为溶剂， 反应 22.5h， 生成 2-isopropyloxy-7-isopropylnaphthalene
  参考文献：
  名称：

  Rapid atropisomerization of 1,1′:5′,1″-ternaphthalene-2,2′,6′,2″-tetrol (TERNOL) and its inhibition by tethering at positions 7 and 7″

  摘要：

  Atropisomerization of 1,1':5',1"-temaphthalene-2,2',6',2"-tetrol (TERNOL) is very fast under basic conditions. The stereochemical instability is attributed to the nature of oxide anion of the central 2,6-naphthodiol moiety. Ring-closing metathesis of 7,7"-diallyloxy TERNOL results in intramolecular tethering in a high yield, which intrinsically inhibits the rapid isomerization. Bidentate sites in the tethered TERNOL are proved to have enough structural flexibility as an axial chiral ligand. (c) 2006 Elsevier Ltd, All rights reserved.

  DOI：

  10.1016/j.tet.2006.12.046

文献信息

• SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
  申请人：Borzilleri Robert M.

  公开号：US20140135318A1

  公开（公告）日：2014-05-15

  Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：W、Q和G的定义如下。还公开了使用这些化合物作为Bcl-2家族抗凋亡蛋白的抑制剂用于治疗癌症的方法；以及包含这些化合物的药物组合物。
• MULTIVALENT FUCOSE DERIVATIVES FOR USE AS A DRUG
  申请人：Nantes Université

  公开号：EP3582789B1

  公开（公告）日：2022-06-22
• US9346795B2
  申请人：——

  公开号：US9346795B2

  公开（公告）日：2016-05-24