N(4)-aminopropylthermine | 13280-93-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N(4)-aminopropylthermine
• 英文别名: N'-[3-[bis(3-aminopropyl)amino]propyl]propane-1,3-diamine
• CAS: 13280-93-8
• 化学式: C₁₂H₃₁N₅
• 分子量: 245.412
• InChiKey: XVQKINPUNPALRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  93.3
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  三(3-氨基丙基)胺 、 在 Thermus thermophilus triamine/agmatine aminopropyltransferase 、 1,4-二巯基-2,3-丁二醇 作用下， 生成 N(4)-aminopropylthermine 、 5'-methylthioadenosine
  参考文献：
  名称：

  嗜热栖热菌三胺/胍丁胺氨基丙基转移酶的晶体结构和酶学性质

  摘要：

  为了在高温环境中维持DNA和RNA的功能构象，嗜热嗜热菌Thermus thermophilus采用独特的多胺生物合成途径，可生产16种以上的多胺。在嗜热基因组中，仅发现一个亚精胺合酶同源物（SpeE），并且被证明是该途径中的关键酶。纯化的酶的催化分析表明，它在氨丙基转移反应中利用三胺（去甲亚精和亚精胺）和胍丁胺作为受体。因此，该酶被称为三胺/胍丁胺氨丙基转移酶（TAAPT）。我们确定了有或没有氨丙基供体S时复合酶的晶体结构-腺苷蛋氨酸。尽管与其他生物的亚精胺合酶在序列和结构上相似，但仍观察到了新型的C末端β-折叠和催化位点的差异。C端模块与守门环相互作用并固定环的开放构象，以识别较大的多胺底物，如胍丁胺和亚精胺。额外的计算对接研究表明，催化位点的结构差异也有助于识别TAAPT底物的氨基丙基/氨基丁基或胍部分。这些结果部分解释了嗜热菌中的多胺谱。

  DOI：

  10.1016/j.jmb.2011.03.025

文献信息

• BENZYLATED MANNICH BASE CURING AGENTS, COMPOSITIONS, AND METHODS
  申请人：EVONIK DEGUSSA GMBH

  公开号：US20170240691A1

  公开（公告）日：2017-08-24

  Compositions and curing agents comprising a benzylated Mannich base composition. The benzylated Mannich base composition includes a reaction product of (a) a substituted phenolic compound having at least one substituent of formula (I): wherein R 1 is each independently a linear or branched alkyl group having 1 to 4 carbon atoms, and R 2 is hydrogen, methyl, ethyl or phenyl, with (b) a benzylated polyalkylene polyamine (II): wherein R A is substituted or unsubstituted benzyl; R B is each independently R A , or a hydrogen atom, or a group selected from C 1 -C 16 linear, cyclic, and branched alkyl, alkenyl, and alkaryl groups; X, Y, and Z are independently selected from C 2 -C 10 alkylene, and cycloalkylene groups; y is an integer from 0 to 7, and z is an integer from 0 to 4; and, optionally, (c) a multifunctional amine. Amine-epoxy compositions and articles produced from these compositions are also disclosed.

  含有苄基曼尼希碱基组分的组合物和固化剂。所述苄基曼尼希碱基组分包括以下反应产物：(a)至少具有一个取代基的取代酚化合物，所述取代基的公式为(I)：其中R1各自独立地是具有1到4个碳原子的线性或支链烷基，R2是氢、甲基、乙基或苯基；(b)苄基化的聚烯烃聚醚胺(II)：其中RA是取代或未取代的苄基，RB各自独立地是RA或氢原子，或选自C1-C16线性、环状和支链烷基、烯基和烷基芳基基团；X、Y和Z各自独立地选自C2-C10烷基和环状烷基基团；y是0到7的整数，z是0到4的整数；可选地，(c)多功能胺。还公开了胺-环氧组合物和由这些组合物制成的物品。
• NITROGEN-CONTAINING HETEROCYCLIC EPOXY CURING AGENTS, COMPOSITIONS AND METHODS
  申请人：Air Products and Chemicals, Inc.

  公开号：US20170137562A1

  公开（公告）日：2017-05-18

  Amine-epoxy curing agents are disclosed including at least one saturated heterocyclic compound having two nitrogen heteroatoms according to formula (I) and at least one saturated fused bicyclic heterocyclic compound having three nitrogen heteroatoms according to formula (II): wherein X is independently selected from a hydrogen atom, a linear or branched C 1 to C 4 alkyl group and a substituted or un-substituted phenyl group, Y 1 is a direct bond or a divalent polyethylene polyamine group having 1 to 8 nitrogen atoms or a divalent polyethylene polyamine derivative having 1 to 8 nitrogen atoms, Y 2 is a direct bond or a divalent polyethylene polyamine group having 1 to 7 nitrogen atoms and R is independently a hydrogen atom or a group selected from C 1 -C 8 linear, cyclic, and branched alkyl, alkenyl, and alkaryl groups.

  本发明揭示了一种氨基-环氧固化剂，其中包括至少一个具有两个氮杂原子的饱和杂环化合物，其符合公式（I）；以及至少一个具有三个氮杂原子的饱和融合双环杂环化合物，其符合公式（II）：其中X独立地选自氢原子、线性或支链C1到C4烷基基团和取代或未取代的苯基基团，Y1是直接键或具有1到8个氮原子的二价聚乙烯多胺基团或具有1到8个氮原子的二价聚乙烯多胺衍生物，Y2是直接键或具有1到7个氮原子的二价聚乙烯多胺基团，R独立地是氢原子或从C1-C8线性、环状和支链烷基、烯基和烷基苯基基团中选择的基团。
• Alkylated Aminopropylated Methylene-Di-(Cyclohexylamine) And Uses Thereof
  申请人：Vedage Gamini Ananda

  公开号：US20090018278A1

  公开（公告）日：2009-01-15

  The present invention provides epoxy curing agent compositions comprising alkylated aminopropylated methylene-di-(cyclohexylamine) compounds. Amine-epoxy compositions and articles produced from these amine-epoxy compositions are also disclosed.

  本发明提供了含有烷基化氨基丙基甲基二(环己胺)化合物的环氧固化剂组合物。还公开了氨基-环氧组合物和由这些氨基-环氧组合物制成的物品。
• Benzylated Polyamine Curing Agents
  申请人：Raymond Williams Rene Edouard

  公开号：US20130079435A1

  公开（公告）日：2013-03-28

  A curing agent composition including at least one benzylated polyamine compound. The benzylated polyamine compound is a reaction product of a benzaldehyde compound or benzyl halide compound and a polyamine according to the following formula: H2N—CH2-A-CH2-NH2 where A is a phenylene group or a cyclohexylene group. A method for making the curing agent composition and an amine-epoxy composition are also disclosed.

  一种固化剂组合物，包括至少一种苯基聚胺化合物。该苯基聚胺化合物是苯甲醛化合物或苯基卤化物化合物和聚胺按以下公式反应产生的产物：H2N—CH2-A-CH2-NH2，其中A是苯基或环己基。还公开了制备固化剂组合物和胺-环氧组合物的方法。
• Alkylated Polyalkylene Polyamines And Uses Thereof
  申请人：Vedage Gamini Ananda

  公开号：US20090029175A1

  公开（公告）日：2009-01-29

  The present invention provides curing agent compositions comprising alkylated polyalkylene polyamine compounds. Amine-epoxy compositions and articles produced from these amine-epoxy compositions are also disclosed.

  本发明提供了包含烷基化聚烯烃聚胺化合物的固化剂组合物。还公开了胺-环氧组合物和由这些胺-环氧组合物制成的制品。