3-(2-Benzo[b]thienyl)-quinuclidine-3-ene | 1102412-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 3-(2-Benzo[b]thienyl)-quinuclidine-3-ene
• 英文别名: 3-(1-Benzothiophen-2-yl)-1-azabicyclo[2.2.2]oct-3-ene
• CAS: 1102412-28-1
• 化学式: C₁₅H₁₅NS
• 分子量: 241.357
• InChiKey: YXLNQVGKJZQLDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 3-Substituted quinuclidines and their use as nicotinic agonists
  申请人：——

  公开号：US20040044026A1

  公开（公告）日：2004-03-04

  This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  该发明涉及新型的3-取代喹诺啡啶衍生物，发现它们在尼古丁乙酰胆碱受体上是胆碱能配体，并且是单胺受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩有关的疾病或紊乱、内分泌疾病或紊乱、神经退行性疾病或紊乱、与炎症有关的疾病或紊乱、疼痛以及因滥用化学物质终止而引起的戒断症状等多种疾病或紊乱具有用处。
• US6884807B2
  申请人：——

  公开号：US6884807B2

  公开（公告）日：2005-04-26