4,5,2'-triphenyl-spiro[furan-2,1'-indan]-3,3'-dione | 107225-79-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4,5,2'-triphenyl-spiro[furan-2,1'-indan]-3,3'-dione
• 英文别名: 3,3'-Dioxo-2',4,5-triphenyl-spiro(furan-2(3H)1'-indan)；4,5,2'-Triphenyl-spiro[furan-2,1'-indan]-3,3'-dion
• CAS: 107225-79-6
• 化学式: C₃₀H₂₀O₃
• 分子量: 428.487
• InChiKey: WIQMRNMRPRSPGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.03
• 重原子数：
  33.0
• 可旋转键数：
  3.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 作用下， 生成 4,5,2'-triphenyl-spiro[furan-2,1'-indan]-3,3'-dione
  参考文献：
  名称：

  Fiesselmann; Ribka, Chemische Berichte, 1956, vol. 89, p. 27,36

  摘要：

  DOI：

文献信息

• The Benefit of Houseofficer Education on Proper Medication Dose Calculation and Ordering
  作者：Lewis S. Nelson、Peter E. Gordon、Marc D. Simmons、William L. Goldberg、Mary Ann Howland、Robert S. Hoffman

  DOI：10.1111/j.1553-2712.2000.tb00481.x

  日期：2000.11

  Abstract. Objectives: Drug dosing errors commonly cause morbidity and mortality. This prospective controlled study was performed to determine: 1) residents' understanding of drug dose calculations and ordering; and 2) the short‐term effect of a brief educational intervention on the skills required to properly calculate dosages and order medications. Methods: The study was conducted at an urban public hospital with a four‐year emergency medicine (EM) residency program. The EM residents served as the study group and were unaware of the study design. A written, eight‐question test (T1) with clinical situations and factual questions was administered. Immediately following the test, correct answers were discussed for 30 minutes. Key concepts were emphasized. Six weeks later, a repeat test (T2a) with a similar format was administered to the study group. The same test (T2b) was simultaneously administered to a control group, residents of similar training who did not take T1, in order to determine test equivalency (T1 vs T2). Tests were graded using explicit criteria by a single investigator blinded to the order of administration. Results: Twenty residents completed both tests T1 and T2a. Their mean scores were 48% and 70%, respectively (p < 0.001, paired t‐test). The control group of ten residents had a mean score of 49% (T2b), similar to the study group's scores on T1 (T1 vs T2b, p = 0.40, unpaired t‐test). Conclusion: Emergency medicine residents require specific training in calculating and executing drug ordering. A brief educational intervention significantly improved short‐term performance when retested six weeks later. Long‐term retention is unknown.
• <b>3-Furanones. I. The Yellow Compound of Kleinfeller and Fiesselmann</b>
  作者：Peter. Yates、Jerry A. Weisbach

  DOI：10.1021/ja00902a018

  日期：1963.10