2-methoxy-1,3,4,5,7,8-hexafluoronaphthalene | 24941-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-methoxy-1,3,4,5,7,8-hexafluoronaphthalene
• 英文别名: 3-Methoxy-1,2,4,5,6,8-hexafluor-naphthalin；1,2,4,5,6,8-Hexafluoro-3-methoxynaphthalene
• CAS: 24941-63-7
• 化学式: C₁₁H₄F₆O
• 分子量: 266.143
• InChiKey: HPVDLFHWQSBXLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,3,4,5,6,7,8-heptafluoronaphthalene 在 /BRN= 3592982/ 作用下， 以 甲醇 为溶剂， 生成 2-methoxy-1,3,4,5,7,8-hexafluoronaphthalene
  参考文献：
  名称：

  Bolton,R.; Sandall,J.P.B., Journal of the Chemical Society. Perkin transactions II, 1978, p. 746 - 750

  摘要：

  DOI：

文献信息

• Mechanisms for reactions of halogenated compounds. Part 5. Orientating effects of fluorine substituents on nucleophilic substitution in naphthalene and other polycyclic systems
  作者：Richard D. Chambers、Mark J. Seabury、D. Lyn H. Williams、Nigel Hughes

  DOI：10.1039/p19880000251

  日期：——

  deactivating when attached directly to these sites. Fluorine at ortho-positions activates. These results enable a simple model, which accounts for orientation of nucleophilic aromatic substitution, to be extended to perfluoropolycyclic compounds.

  在多氟萘中，相对于甲醇中甲醇的攻击位置，已经确定了氟原子作为邻位和远端环上取代基的取代基的单独活化作用。氟在过渡态中邻近高电荷密度中心的远端环中的位点激活，但直接连接到这些位点时，氟会略微失活。邻位的氟被激活。这些结果使一个简单的模型，其解释了亲核芳香族取代的方向，可以扩展到全氟多环化合物。
• Partially fluorinated heterocyclic compounds. Part 26[1]. An investigation into the mode of cyclisation in the reaction of lithium 1,3,4,5,6,7,8-heptafluoro-2-naphthalenethiolate with dimethyl acetylenedicarboxylate
  作者：Gerald M. Brooke

  DOI：10.1016/s0022-1139(00)82726-8

  日期：1989.6

  Octafluoronaphthalene reacted with sodium hydrosulphide to give 1,3,4,5,6,7,8-heptafluoro-2-naphthalenethiol (4). The lithium salt of (4) and dimethyl acetylenedicarboxylate gave dimethyl 4,5,6,7,8,9-hexafluoronaphtho[2,1-b]thiophen-1,2- dicarboxylate (6) and dimethyl 4,5,6,7,8,9-hexafluoronaphtho[2,3-b] thiophen-2,3-dicarboxylate (7) in the ratio of 92:8 respectively via intramolecular cyclisation

  八氟萘与硫化氢钠反应生成1,3,4,5,6,7,8-七氟-2-萘硫醇（4）。（4）的锂盐和乙炔二羧酸二甲酯形成4,5,6,7,8,9-六氟萘二甲基[2,1-b]噻吩1,2-二羧酸二甲酯（6）和4,5,6二甲基，通过分子内环化反应分别以92：8的比例合成7,8,9-六氟萘[2,3-b]噻吩-2,3-二羧酸酯（7）。通过水解和脱羧，将化合物（6）转化为4,5,6,7,8,9-六氟萘并[2,1-b]噻吩（8）。甲醇中的甲醇钠取代了1,3,4,5,6,7,8-七氟-2-萘甲基硫化物中的6-F氟（12）。通过在中间体（5）中的1-F处取代氟来优选形成（6），表明对局部能的考虑提高了该取向反应的选择性。
• BROOKE, GERALD M., J. FLUOR. CHEM., 43,(1989) N, C. 393-403
  作者：BROOKE, GERALD M.

  DOI：——

  日期：——
• CHAMBERS, RICHARD D.;SEABURY, MARK J.;WILLIAMS, D. LYN H.;HUGHES, NIGEL, J. CHEM. SOC. PERKIN TRANS.,(1988) N 2, 251-254
  作者：CHAMBERS, RICHARD D.、SEABURY, MARK J.、WILLIAMS, D. LYN H.、HUGHES, NIGEL

  DOI：——

  日期：——
• PATTERN FORMING METHOD USING DEVELOPER CONTAINING ORGANIC SOLVENT AND RINSING SOLUTION FOR USE IN THE PATTERN FORMING METHOD
  申请人：Kamimura Sou

  公开号：US20110229832A1

  公开（公告）日：2011-09-22

  A pattern forming method, includes: (i) a step of forming a resist film from a resist composition for organic solvent-based development, the resist composition containing (A) a resin capable of increasing a polarity by an action of an acid to decrease a solubility in an organic solvent-containing developer and (B) a compound capable of generating an acid upon irradiation with an actinic ray or radiation; (ii) an exposure step; (iii) a development step using an organic solvent-containing developer; and (iv) a washing step using a rinsing solution, wherein in the step (iv), a rinsing solution containing at least either the solvent S 1 or S 2 as defined in the specification is used.