3-Pyridin-3-yl-N-pyridin-2-yl-acrylamide | 340258-51-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Pyridin-3-yl-N-pyridin-2-yl-acrylamide
• 英文别名: (E)-N-pyridin-2-yl-3-pyridin-3-ylprop-2-enamide
• CAS: 340258-51-7
• 化学式: C₁₃H₁₁N₃O
• 分子量: 225.25
• InChiKey: QILQPJFHMUUJIW-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Utilities of amide compounds
  申请人：——

  公开号：US20040235888A1

  公开（公告）日：2004-11-25

  Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): 1 in which ring A and Ar 1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y 1 and Y 2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.

  提供了一种具有增强apoAI表达活性的化合物，可用作药物。公开了式（I）的化合物：其中环A和Ar1分别是单环或双环芳香碳环族或芳香杂环族，每个都可以选择性地被取代，或类似物; R是氢或类似物; Z是氧或类似物; Y1和Y2是氢，较低的烷基或类似物; n是0到2的整数; 断线表示键的存在或不存在; 波浪线表示相对于双键的顺反式异构。
• New utilities of amide compounds
  申请人：Yamamori Teruo

  公开号：US20080221112A1

  公开（公告）日：2008-09-11

  Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar 1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y 1 and Y 2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
• US7429593B2
  申请人：——

  公开号：US7429593B2

  公开（公告）日：2008-09-30
• US8106051B2
  申请人：——

  公开号：US8106051B2

  公开（公告）日：2012-01-31