1,10-Diazabicyclo<8,8,8>-hexacosan | 19757-26-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,10-Diazabicyclo<8,8,8>-hexacosan
• 英文别名: 1,10-Diazabicyclo[8.8.8]hexacosane
• CAS: 19757-26-7
• 化学式: C₂₄H₄₈N₂
• 分子量: 364.659
• InChiKey: LZCDQAMEXVLJFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Method of preparing fluorine-18 labeled Cabozantinib and its analogs
  申请人：Exelixis, Inc.

  公开号：US11124481B2

  公开（公告）日：2021-09-21

  The present invention relates to a method of preparing Cabozantinib (Cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinolin-4-yloxy)-phenylo]amide(4-fluoro-phenyl)amide) and 18F labeled Cabozantinib.

  本发明涉及一种制备卡博替尼（Cabozantinib）（环丙烷-1,1-二羧酸[4-(6,7-二甲氧基-喹啉-4-氧基)-苯基]酰胺（4-氟苯基）酰胺）和 18F 标记的卡博替尼的方法。
• Ion specific analytical element
  申请人：MILES INC.

  公开号：EP0041175B1

  公开（公告）日：1985-11-21
• Method of preparing erythromycin A cyclic 11,12-carbonate
  申请人：Tarchominskie Zaklady Farmaceutyczne "Polfa"

  公开号：EP0119431B1

  公开（公告）日：1987-09-16
• RADIOLABELLED FLUOROBENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING
  申请人：Washington University

  公开号：EP2164327A2

  公开（公告）日：2010-03-24
• FORMATION AND USES OF EUROPIUM
  申请人：WAYNE STATE UNIVERSITY

  公开号：US20160022842A1

  公开（公告）日：2016-01-28

  An MRI contrast composition includes a liposome and a europium metal complex disposed within the liposome. The europium metal complex includes a europium metal ion and a multi-dentate ligand selected from the group consisting of cryptands and thiacryptands and one or more counter-ions that balances a charge of the europium metal ion and the multi-dentate ligand, the europium metal ion being switchable between a 2+ and 3+ oxidation state. The contrast composition advantageously provides an oxidation-responsive dual-mode contrast agent because it would enhance either T 1 -weighted images or CEST images depending on the oxidation state of Eu.