1-tert-butyl-2-isopropyl-aziridine | 54697-55-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-tert-butyl-2-isopropyl-aziridine
• 英文别名: 1-Tert-butyl-2-propan-2-ylaziridine
• CAS: 54697-55-1
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: GUSIJRNXZLEVKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-1-(2,2-dichloro-3-methylbutylidene)t-butylamine 、 氢化铝锂 生成 1-tert-butyl-2-isopropyl-aziridine
  参考文献：
  名称：

  DE KIMPE N.; VERHE R.; DE BUYCK L.; SCHAMP N., SYNTH. COMMUN., 1975, 5, NO 4, 269-274

  摘要：

  DOI：

文献信息

• Melanocortin receptor-specific peptides
  申请人：Palatin Technologies, Inc.

  公开号：US10179804B2

  公开（公告）日：2019-01-15

  Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and z are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes.

  式中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和z如说明书中所定义的黑色素皮质素受体特异性环肽，包括前述式中肽的组合物和制剂，以及预防、改善或治疗黑色素皮质素受体介导的疾病、适应症、条件和综合征的方法。
• GLUTAMINASE INHIBITORS
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20170290815A1

  公开（公告）日：2017-10-12

  A compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein A is a ring; Y 1 and Y 2 are each independently N or C with the proper valency; X 1 and X 2 are each independently —NH—, —O—, —CH 2 —O—, —NH—CH 2 —, or —N(CH 3 )—CH 2 —, provided that when at least one of X 1 and X 2 is —CH 2 —O—, —NH—CH 2 —, or —N(CH 3 )—CH 2 — then the —CH 2 — is directly connected to A; a and b are each independently 0 or 1; c and d are each independently 0 or 1; Z 1 and Z 2 are each independently a heterocyclic; and R 1 and R 2 are each independently optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, amino, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl; provided that if Y 1 and Y 2 are each C, then a is 1 and b is 1; provided that if Y 1 and Y 2 are each N, then a is 0 and b is 0; provided that if Y 1 is N and Y 2 is C, then a=0 and b=1; provided that if Y 1 is C and Y 2 is N, then a=1 and b=0; provided that if c=0 and d=0, then R 1 and R 2 are both amino; provided that if c is 1 and d is 1, then both R 1 and R 2 are not amino; provided that if c is 0 and d is 1, then R 1 is amino and R 2 is optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl; and provided that if c is 1 and d is 0, then R 2 is amino and R 1 is optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl.