Dimethyl-(3-methyl-1-propyl-butyl)-amine | 33781-05-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Dimethyl-(3-methyl-1-propyl-butyl)-amine
• 英文别名: N,N,2-trimethylheptan-4-amine
• CAS: 33781-05-4
• 化学式: C₁₀H₂₃N
• 分子量: 157.299
• InChiKey: LZHPSRLAKYBAJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] COMPOUNDS INHIBITORS OF METTL3<br/>[FR] COMPOSÉS INHIBITEURS DE METTL3
  申请人：STORM THERAPEUTICS LTD

  公开号：WO2022074391A1

  公开（公告）日：2022-04-14

  The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W-X-Y-Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activityis implicated.

  本发明涉及式（I）的化合物，其作为METTL3（N6-腺苷甲基转移酶70 kDa亚基）酶活性的抑制剂：W-X-Y-Z（I），其中X、Y和Z的定义如本文所述。本发明还涉及制备这些化合物的过程，包括它们的制药组合物以及它们在治疗增殖性疾病（如癌症）和自身免疫性疾病以及其他METTL3活性有所涉及的疾病或情况中的使用。
• IMIDATE COMPOUND AND USE THEREOF FOR PEST CONTROL
  申请人：Kamiyama Hideo

  公开号：US20100210683A1

  公开（公告）日：2010-08-19

  There is provided a compound having an excellent controlling effect on arthropod pests represented by the formula (I-1): wherein Z represents an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; G represents a -A 1 -R 1 group, etc.; X 0 represents a -A 2 -R 4 group, etc.; X represents a -A 2 -R 4 group, etc.; X 0 represents a -A 3 -R 6 group, etc.; or X and X 0 are optionally taken together to form a -A 2 -T 0 -A 3 - group; M 1 represents a —R 8 group, etc.; A 1 , A 2 and A 3 independently represent an oxygen atom, etc.; R 1 and R 8 independently represents an optionally substituted C1-C20 chain hydrocarbon group, etc.; R 4 and R 6 independently represent an optionally substituted C1-C6 chain hydrocarbon group, etc.; and T 0 represents an optionally substituted C2-C6 alkanediyl group.

  提供一种化合物，它对于以式(I-1)所代表的节肢动物害虫具有优异的控制效果：其中Z代表可选取代的碳环基团或可选取代的杂环基团；G代表-A1-R1基团等；X0代表-A2-R4基团等；X代表-A2-R4基团等；X0代表-A3-R6基团等；或X和X0可选地结合形成-A2-T0-A3-基团；M1代表-R8基团等；A1、A2和A3独立地代表氧原子等；R1和R8独立地代表可选取代的C1-C20链烃基团等；R4和R6独立地代表可选取代的C1-C6链烃基团等；而T0代表可选取代的C2-C6脂肪二基基团。
• Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof
  申请人：Hardy Larry Wendell

  公开号：US20110319380A1

  公开（公告）日：2011-12-29

  Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

  本文提供了化合物及其合成方法。本文中提供的化合物可用于治疗、预防和/或管理各种疾病，如神经系统疾病、神经退行性疾病、神经精神疾病、认知、学习或记忆障碍、胃肠道疾病、下尿路障碍和癌症。本文提供的化合物在中枢神经系统或外周调节代谢性谷氨酸受体5(mGluR5)的活性。本文还提供了含有这些化合物的药物制剂及其使用方法。
• Inhibitors of transglutaminases
  申请人：Zedira GmbH

  公开号：US11072634B2

  公开（公告）日：2021-07-27

  The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.

  本发明涉及作为新型转谷氨酰胺酶抑制剂的通式（I）化合物、生产本发明化合物的方法、含有所述本发明化合物的药物组合物以及它们在预防和治疗与转谷氨酰胺酶有关的疾病方面的用途。
• PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF
  申请人：SANOFI

  公开号：EP2791137B1

  公开（公告）日：2019-01-23