7-O-Demethyljanex-1 | 406484-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-O-Demethyljanex-1
• 英文别名: 4-(4-hydroxyanilino)-6-methoxyquinazolin-7-ol
• CAS: 406484-24-0
• 化学式: C₁₅H₁₃N₃O₃
• 分子量: 283.28
• InChiKey: WKTLTDLVYQTHFO-UHFFFAOYSA-N

物化性质

• 沸点：
  495.8±40.0 °C(Predicted)
• 密度：
  1.438±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  87.5
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF VITILIGO<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU VITILIGO
  申请人：ACLARIS THERAPEUTICS INC

  公开号：WO2019040706A1

  公开（公告）日：2019-02-28

  Methods of treating vitiligo using JAK/STAT modulating compounds are provided herein. The JAK/STAT modulating compounds may be selected from 5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one, disodium (5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methylpyrimidin-4-yl)amino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate, tofacitinib, ruxolitinib, baricitinib, lestaurtinib, decernotinib, TG101348, Janex 1, PF-956980, WHI-P154, ZM-39923, NSC114792, cerdulatinib, fedratinib, PF-06263276, CEP-33779, AZD-1480, SHR0302, oclacitinib, filgotinib, gandotinib, momelotinib, pacritinib, upadacitinib, peficitinib, PF-04965842, N-(3-acetamido-5-(quinaxalin-2-yl) phenyl) acrylamide, 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate (PF-06651600), [(1S)-2,2-Difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-methanone tosylate, a derivative thereof, or a combination thereof. The JAK/STAT modulating compounds may be formulated for topical or oral delivery.