1,3-bis[(1'-(4-methylbenzyl)-1',3'-dihydro-1H-[3,3']biindolyl-2'-on)-1-yl]propane | 1356031-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,3-bis[(1'-(4-methylbenzyl)-1',3'-dihydro-1H-[3,3']biindolyl-2'-on)-1-yl]propane
• CAS: 1356031-36-1
• 化学式: C₅₁H₄₄N₄O₂
• 分子量: 744.936
• InChiKey: IABDDKFGDNGQJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.66
• 重原子数：
  57.0
• 可旋转键数：
  10.0
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  50.48
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1-(3-(1H-indol-1-yl)propyl)-1H-indole 、 3-diazo-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one 在 dirhodium tetraacetate 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 以95%的产率得到1,3-bis[(1'-(4-methylbenzyl)-1',3'-dihydro-1H-[3,3']biindolyl-2'-on)-1-yl]propane
  参考文献：
  名称：

  Rhodium(II) catalyzed intermolecular double C-alkylation: a method for the synthesis of tetraindoles and indolophanes

  摘要：

  Double C-alkylation of cyclic diazoamides or bis-diazoamides with indoles or bis-indoles has been achieved to synthesize tetraindole derivatives using rhodium(II) acetate as a catalyst under mild reaction conditions with complete regioselectivity. The intermolecular double C-alkylation reaction strategy was successfully applied to synthesize indolophanes in moderate yield with excellent regiocontrol. The structure and stereochemistry of macrocycles were unequivocally confirmed with the help of single-crystal X-ray structure analyses. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.073