4-己氧基萘-1-甲腈 | 66052-05-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-己氧基萘-1-甲腈
• 英文名称: 4-hexyloxy-[1]naphthonitrile
• 英文别名: 4-Hexyloxy-[1]naphthonitril；4-hexyloxynaphthalene-1-carbonitrile；4-Hexyloxy-1-naphthonitril；4-hexoxynaphthalene-1-carbonitrile
• CAS: 66052-05-9
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: DYLLLOIDOOTBBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-溴-4-(己氧基)-萘 、 氰化亚铜 在 吡啶 作用下， 生成 4-己氧基萘-1-甲腈
  参考文献：
  名称：

  2-(Alkoxyaryl)-2-imidazoline monoamine oxidase inhibitors with antidepressant activity

  摘要：

  Unlike the related noncyclic amidines which are broad-spectrum cestocides, a number of 2-imidazolines substituted in the 2 position by alkoxyaryl groups were not highly active in screening tests against the mouse tapeworms Hymenolepsis nana and Oochoristica symmetrica. Certain of the 2-(4-alkoxynaphthyl)-2-imidazolines and 2-(6-alkoxy-2-naphthyl)-2-imidzolines, however, had activity interpreted as antidepressant in the mouse. This activity paralleled in vitro irreversible inhibitory activity against mouse brain MAO for those where no substitution is present on the imidazoline ring. This irreversibility probably has a different origin from that postulated to explain the irreversible MAO inhibition of proparglic, cyclopropyl, and other "chemically reactive" MAO inhibitors.

  DOI：

  10.1021/jm00202a021

文献信息

• MIXAJLYUK, A. N.;XOMUTOV, M. A.;BELENKIJ, L. I.;DANILOV, V. A.;BARYSHEVA,+
  作者：MIXAJLYUK, A. N.、XOMUTOV, M. A.、BELENKIJ, L. I.、DANILOV, V. A.、BARYSHEVA,+

  DOI：——

  日期：——
• 2-(Alkoxyaryl)-2-imidazoline monoamine oxidase inhibitors with antidepressant activity
  作者：Morton Harfenist、Francis E. Soroko、Gerald M. McKenzie

  DOI：10.1021/jm00202a021

  日期：1978.4

  Unlike the related noncyclic amidines which are broad-spectrum cestocides, a number of 2-imidazolines substituted in the 2 position by alkoxyaryl groups were not highly active in screening tests against the mouse tapeworms Hymenolepsis nana and Oochoristica symmetrica. Certain of the 2-(4-alkoxynaphthyl)-2-imidazolines and 2-(6-alkoxy-2-naphthyl)-2-imidzolines, however, had activity interpreted as antidepressant in the mouse. This activity paralleled in vitro irreversible inhibitory activity against mouse brain MAO for those where no substitution is present on the imidazoline ring. This irreversibility probably has a different origin from that postulated to explain the irreversible MAO inhibition of proparglic, cyclopropyl, and other "chemically reactive" MAO inhibitors.