KP 27301 | 442660-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: KP 27301
• 英文别名: 5-(N-(1-naphthyl)amino)-1,2,3-thiadiazole-4-carboxamide；5-(Naphthalen-1-ylamino)-[1,2,3]thiadiazole-4-carboxylic acid amide；5-(Naphthalen-1-ylamino)thiadiazole-4-carboxamide
• CAS: 442660-88-0
• 化学式: C₁₃H₁₀N₄OS
• 分子量: 270.315
• InChiKey: WWWJZOOFMLPYFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Antiproliferative 1,2,3-thiadiazole compounds
  申请人：——

  公开号：US20030096848A1

  公开（公告）日：2003-05-22

  Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are 1,2,3-thiadiazoles having the structure: 1 and including stereoisomers, solvates, and pharmaceutically acceptable salts thereof, wherein each of R 1 , R 2 , R 3 and R 4 is independently selected from hydrogen, R 5 , R 6 , and R 7 ; R 5 is selected from alkyl, heteroalkyl, aryl and heteroaryl; R 6 is selected from (R 5 ) n -alkylene, (R 5 ) n -heteroalkylene, (R 5 ) n -arylene and (R 5 ) n -heteroarylene; R 7 is selected from (R 6 ) n -alkylene, (R 6 ) n -heteroalkylene, (R 6 ) n -arylene, and (R 6 ) n -heteroarylene; and n is selected from 0, 1, 2, 3, 4 and 5, where R 1 and R 2 may together form a heterocyclic structure including the nitrogen to which they are both attached, and R 3 and R 4 may together form a heterocyclic structure including the nitrogen to which they are both attached; and each of L 1 and L 2 is independently selected from -A1-A2-A3- where each of A1, A2, and A3 is independently selected from a direct bond, alkylene, heteroalkylene, arylene and heteroarylene.

  提供药物组合物和化合物。本发明的化合物具有抗增殖活性，可能促进缺乏正常细胞周期和死亡调节的细胞凋亡。在本发明的一个实施例中，提供了与生理可接受载体结合的化合物配方。这些药物配方在治疗过度增殖性疾病方面很有用，这些疾病包括肿瘤生长、淋巴增殖性疾病和血管生成。本发明的化合物是具有以下结构的1,2,3-噻二唑：1，包括立体异构体、溶剂化合物和其药用可接受盐，其中R1、R2、R3和R4中的每一个都是独立选择的氢、R5、R6和R7；R5选择自烷基、杂原子烷基、芳基和杂芳基；R6选择自（R5）n-烷基、（R5）n-杂原子烷基、（R5）n-芳基和（R5）n-杂芳基；R7选择自（R6）n-烷基、（R6）n-杂原子烷基、（R6）n-芳基和（R6）n-杂芳基；n选择自0、1、2、3、4和5，其中R1和R2可以共同形成包括它们共同连接的氮的杂环结构，R3和R4可以共同形成包括它们共同连接的氮的杂环结构；L1和L2中的每一个都是独立选择自-A1-A2-A3-，其中A1、A2和A3中的每一个都是独立选择自直接键、烷基、杂原子烷基、芳基和杂芳基。
• US6420400B1
  申请人：——

  公开号：US6420400B1

  公开（公告）日：2002-07-16
• US7022702B2
  申请人：——

  公开号：US7022702B2

  公开（公告）日：2006-04-04
• US7288556B2
  申请人：——

  公开号：US7288556B2

  公开（公告）日：2007-10-30