| 909022-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 909022-88-4
• 化学式: C₄₂H₃₄O
• 分子量: 554.731
• InChiKey: HDQZELGQWNXIQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.25
• 重原子数：
  43.0
• 可旋转键数：
  3.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  在 potassium tert-butylate 、 三溴化硼 作用下， 以 异丁醇 、 甲苯 、 二氯甲烷 为溶剂， 反应 9.0h， 以42%的产率得到2-(5-benzo[b]fluorenyl)-2'-hydroxy-1,1'-binaphthyl
  参考文献：
  名称：

  Synthesis and separation of the atropisomers of 2-(5-benzo[b]fluorenyl)-2′-hydroxy-1,1′-binaphthyl and related compounds

  摘要：

  Several syn and anti atropisomers of 2-(5-benzo[b]fluorenyl)-2'-hydroxy-1,1'-binaphthyl and related compounds were synthesized from 1,1'-binaphthyl-2,2'-diol (BINOL). It was possible to separate the syn and anti atropisomers by silica gel column chromatography. The syn atropisomers are potential hetero-bidentate ligands for complex formation with metals. By starting from enantiomerically pure (R)-(+)-BINOL and (S)-(-)-BINOL, four optically active syn atropisomers and two anti atropisomers with high enantiomeric purity were obtained. The structures of two syn atropisomers and one anti atropisomer were established by X-ray structure analyses. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.06.004
• 作为产物：
  描述：

  (R)-1,1'-Bi-2-naphthol 在 四(三苯基膦)钯 、 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) 吡啶 、 三乙基硅烷 、 sodium hydroxide 、 sodium periodate 、 N-溴代丁二酰亚胺(NBS) 、 copper(l) iodide 、 正丁基锂 、 偶氮二异丁腈 、 potassium carbonate 、 二异丙胺 、 三氟乙酸 作用下， 以 甲醇 、 乙醚 、 正己烷 、 二氯甲烷 、 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and separation of the atropisomers of 2-(5-benzo[b]fluorenyl)-2′-hydroxy-1,1′-binaphthyl and related compounds

  摘要：

  Several syn and anti atropisomers of 2-(5-benzo[b]fluorenyl)-2'-hydroxy-1,1'-binaphthyl and related compounds were synthesized from 1,1'-binaphthyl-2,2'-diol (BINOL). It was possible to separate the syn and anti atropisomers by silica gel column chromatography. The syn atropisomers are potential hetero-bidentate ligands for complex formation with metals. By starting from enantiomerically pure (R)-(+)-BINOL and (S)-(-)-BINOL, four optically active syn atropisomers and two anti atropisomers with high enantiomeric purity were obtained. The structures of two syn atropisomers and one anti atropisomer were established by X-ray structure analyses. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.06.004

文献信息

• Synthesis of 5-(2-methoxy-1-naphthyl)- and 5-[2-(methoxymethyl)-1-naphthyl]-11<i>H</i>-benzo[<i>b</i>]fluorene as 2,2'-disubstituted 1,1'-binaphthyls via benzannulated enyne–allenes
  作者：Yu-Hsuan Wang、Joshua F Bailey、Jeffrey L Petersen、Kung K Wang

  DOI：10.3762/bjoc.7.58

  日期：——

  to give benzannulated enyne-allenes for the subsequent Schmittel cascade cyclization reactions. The structures of these two 5-(1-naphthyl)-11H-benzo[b]fluorenes could be regarded as 2,2'-disubstituted 1,1'-binaphthyls with the newly constructed benzofluorenyl group serving as a naphthyl moiety.

  5-(2-Methoxy-1-naphthyl)-和5-[2-(甲氧基甲基)-1-naphthyl]-11H-苯并[b]芴通过用叔丁醇钾回流处理相应的苯并环化烯二炔合成甲苯生成苯并环化的烯炔-丙二烯，用于随后的施密特级联环化反应。这两种 5-(1-萘基)-11H-苯并 [b] 芴的结构可以看作是 2,2'-二取代的 1,1'-联萘，新构建的苯并芴基作为萘基部分。