(6R,8S)-1-(2,2-Dimethyl-propionyl)-5-trityloxymethyl-1,6,7,8-tetrahydro-cyclopenta[g]indole-6,8-dicarbaldehyde | 176980-00-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (6R,8S)-1-(2,2-Dimethyl-propionyl)-5-trityloxymethyl-1,6,7,8-tetrahydro-cyclopenta[g]indole-6,8-dicarbaldehyde
• 英文别名: (6R,8S)-1-(2,2-dimethylpropanoyl)-5-(trityloxymethyl)-7,8-dihydro-6H-cyclopenta[g]indole-6,8-dicarbaldehyde
• CAS: 176980-00-0
• 化学式: C₃₈H₃₅NO₄
• 分子量: 569.7
• InChiKey: SNARCVAEPCROCF-WUFINQPMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  65.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (6R,8S)-1-(2,2-Dimethyl-propionyl)-5-trityloxymethyl-1,6,7,8-tetrahydro-cyclopenta[g]indole-6,8-dicarbaldehyde 在 manganese(IV) oxide 、 sodium tetrahydroborate 、 18-冠醚-6 、 D(+)-10-樟脑磺酸 、 sodium hydride 、 三乙胺 、 sodium iodide 、 锌 作用下， 以 四氢呋喃 、 甲醇 、 乙二醇二甲醚 、 乙醚 、 二氯甲烷 为溶剂， 反应 26.0h， 生成 (6R,8S)-1-Acetyl-6,8-dimethyl-1,6,7,8-tetrahydro-cyclopenta[g]indole-5-carbaldehyde
  参考文献：
  名称：

  Enantioselective Total Synthesis of cis-Trikentrin B

  摘要：

  Natural cis-trikentrin B was synthesized enantioselectively using, as key steps, an intramolecular Diels-Alder reaction of an allenic dienamide followed by aromatization to construct an indole ring and cleavage of bicyclo[2.2.1]heptene to launch a cis-dimethylcyclopentane ring. Diels-Alder adducts 9 and 10 were elaborated to provide allenic dienamide 25, and its intramolecular Diels-Alder reaction proceeded smoothly. Aromatization to an indole ring and stereoselective cleavage of the bicyclo[2.2.1]heptene ring were performed successfully. Introduction of an (E)-butenyl group via addition of propylmagnesium bromide and subsequent anti elimination of water gave natural cis-trikentrin B.

  DOI：

  10.1021/jo951767q
• 作为产物：
  描述：

  (6S,9R)-1-(2,2-dimethyl-1-oxopropyl)-6,7,8,9-tetrahydro-5-[(triphenylmethoxy)methyl]-7,8-dihydroxy-6,9-methano-1H-benz[g]indole 在 sodium periodate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以96%的产率得到(6R,8S)-1-(2,2-Dimethyl-propionyl)-5-trityloxymethyl-1,6,7,8-tetrahydro-cyclopenta[g]indole-6,8-dicarbaldehyde
  参考文献：
  名称：

  Enantioselective Total Synthesis of cis-Trikentrin B

  摘要：

  Natural cis-trikentrin B was synthesized enantioselectively using, as key steps, an intramolecular Diels-Alder reaction of an allenic dienamide followed by aromatization to construct an indole ring and cleavage of bicyclo[2.2.1]heptene to launch a cis-dimethylcyclopentane ring. Diels-Alder adducts 9 and 10 were elaborated to provide allenic dienamide 25, and its intramolecular Diels-Alder reaction proceeded smoothly. Aromatization to an indole ring and stereoselective cleavage of the bicyclo[2.2.1]heptene ring were performed successfully. Introduction of an (E)-butenyl group via addition of propylmagnesium bromide and subsequent anti elimination of water gave natural cis-trikentrin B.

  DOI：

  10.1021/jo951767q